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Literature summary for 2.7.11.24 extracted from

  • Lee, S.J.; Park, S.S.; Lee, U.S.; Kim, W.J.; Moon, S.K.
    Signaling pathway for TNF-alpha-induced MMP-9 expression: Mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells (2008), Int. Immunopharmacol., 8, 1821-1826.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
TNF-alpha p38 MAP kinase is significantly activated by TNF-alpha, however, activation of ERK1/2 and JNK remain essentially unchanged. TNF-alpha-induced phosphorylation of the p38 MAP kinase is inhibited by SB203580 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
SB203580 inhibitor of p38 MAP kinase, inhibition of the activation by TNF-alpha Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + MMP-9 Homo sapiens activity of p38 MAP kinase, TNF-alpha stimulates MMP-9 expression via the p38 MAP kinase signaling pathway in 5637 cells, and p38 MAP kinase-mediated MMP-9 gene regulation in response to TNF-alpha is involved in the NF-kappaB response element in 5637 cells, regulation, overview ADP + phosphorylated MMP-9
-
 ?
additional information Homo sapiens p38 MAP kinase inhibitor SB203580 decreases TNF-alpha-mediated DNA binding activity of NF-?B, which is is involved in p38MAP kinase-mediated control of the MMP-9 gene in 5637 cells, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
5637 cell urinary bladder cancer cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + MMP-9 activity of p38 MAP kinase, TNF-alpha stimulates MMP-9 expression via the p38 MAP kinase signaling pathway in 5637 cells, and p38 MAP kinase-mediated MMP-9 gene regulation in response to TNF-alpha is involved in the NF-kappaB response element in 5637 cells, regulation, overview Homo sapiens ADP + phosphorylated MMP-9
-
 ?
ATP + MMP-9 activity of p38 MAP kinase Homo sapiens ADP + phosphorylated MMP-9
-
 ?
additional information p38 MAP kinase inhibitor SB203580 decreases TNF-alpha-mediated DNA binding activity of NF-?B, which is is involved in p38MAP kinase-mediated control of the MMP-9 gene in 5637 cells, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
p38 MAP kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens