Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | JNK-1 is activated by phosphorylation, ambient temperature of 1-37°C specifically influences the activation/phosphorylation of the MAPkinase JNK-1 | Caenorhabditis elegans |
Application | Comment | Organism |
---|---|---|
additional information | indirect interactions between neuronal MAPK and peripheral insulin-like signaling in response to environmental stimuli (temperature, H2O2) | Caenorhabditis elegans |
Protein Variants | Comment | Organism |
---|---|---|
additional information | transgenic jnk-1 deletion mutant, exhibits a reduced thermal tolerance and reproductive fitness at higher temperatures | Caenorhabditis elegans |
additional information | construction of a JNK-1 deletion mutant expressing daf-16-GFP, the mutant exhibits a reduced thermal tolerance and reproductive fitness at higher temperatures compared to the wild-type enzyme, jnk-1 overexpression leads to enhanced translocation of DAF-16 | Caenorhabditis elegans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Caenorhabditis elegans | promoting influence of JNK-1 on both nuclear DAF-16 translocations and DAF-16 target gene sod-3, encoding superoxide dismutase 3, expressions within peripheral, non-neuronal tissue, JNK-1 modulates the intestinal stress-induced translocation of DAF-16 from the cytosol into the cell nucleus. JNK-1 is controlled by the MAPK JKK-1 under heat stress | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Caenorhabditis elegans | Q8WQG9 | several strains | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | JNK-1 is activated by phosphorylation, ambient temperature of 1-37°C specifically influences the activation/phosphorylation of the MAPkinase JNK-1 | Caenorhabditis elegans |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
nerve | nerve ring | Caenorhabditis elegans | - |
neuronal cell | activated JNK-1 observed only in neuronal cells | Caenorhabditis elegans | - |
neuronal cell | JNK-1 is specific for neuronal cells | Caenorhabditis elegans | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | promoting influence of JNK-1 on both nuclear DAF-16 translocations and DAF-16 target gene sod-3, encoding superoxide dismutase 3, expressions within peripheral, non-neuronal tissue, JNK-1 modulates the intestinal stress-induced translocation of DAF-16 from the cytosol into the cell nucleus. JNK-1 is controlled by the MAPK JKK-1 under heat stress | Caenorhabditis elegans | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
JNK-1 | - |
Caenorhabditis elegans |
MAP kinase | - |
Caenorhabditis elegans |
MAPK | - |
Caenorhabditis elegans |
mitogen-activated protein kinase | - |
Caenorhabditis elegans |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
ambient temperature of 1-37°C specifically influences the activation/phosphorylation of the MAPkinase JNK-1 | Caenorhabditis elegans |
15 | 20 | rise of degree of phosphorylation of isoforms JNK-1alpha and JNK-1beta | Caenorhabditis elegans |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
1 | 37 | degree of phosphorylation of isoforms JNK-1alpha and JNK-1beta increase with ambient temperature | Caenorhabditis elegans |