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Literature summary for 2.7.11.24 extracted from

  • Lewthwaite, J.C.; Bastow, E.R.; Lamb, K.J.; Blenis, J.; Wheeler-Jones, C.P.; Pitsillides, A.A.
    A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation (2006), J. Biol. Chem., 281, 11011-11018.
    View publication on PubMed
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
additional information mechanical strain activates ERK but not p38 MAPK. ERK1/2, but not p38 MAPK, exhibits dose-dependent FGF2-, epidermal growth factor- or sodium pervanadate-induced activation Gallus gallus

Application

Application Comment Organism
additional information constitutively active p38 MAPK serves an essential, permissive role in mechanically induced changes in ERK activation and in the accumulation of hyaluronan-rich extracellular matrices that serve a key role in joint development, constitutively active p38 influences the duration and extent of ERK1/2 activation and hyperphosphorylation of one of its downstream targets c-Fos Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition of the MEK-ERK pathway by either U0126 or PD98059 has no discernable effect on p38 MAPK phosphorylation, U0126 treatment also fails to modify pervanadate-induced p38 MAPK activity Gallus gallus
SB202190 selective to p38 MAPKalpha and -beta isoforms, enhances strain-induced ERK1/2 activation but also restricts strain-induced ERK1/2 activation at longer times Gallus gallus
SB202190 inhibition of p38 MAPK and modulation of ERK, enhanced strain-induced ERK1/2 activation at 20 min and its restriction after 24 h Rattus norvegicus
SB203580 selective to p38 MAPKalpha and -beta isoforms, addition to AS cells reveals marked reduction in coat size, both basal and strain-induced hyaluronan release is significantly reduced, enhances strain-induced ERK1/2 activation but also restricts strain-induced ERK1/2 activation at longer times Gallus gallus
SB203580 inhibition of p38 MAPK and modulation of ERK, enhanced strain-induced ERK1/2 activation at 20 min and its restriction after 24 h Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Gallus gallus 5737
-

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
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 Gallus gallus
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epiphysis chondrocytes in epiphyses and bordering vascular canals express lower levels of total (inactive plus active) and active p38 MAPK Gallus gallus
-
additional information AS cell, inactive plus active p38 MAPK is predominantly expressed in cells of the fibrocartilaginous articular surface of joint elements Gallus gallus
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osteoblast
-
 Rattus norvegicus
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Synonyms

Synonyms Comment Organism
ERK1/2
-
 Gallus gallus
ERK1/2
-
 Rattus norvegicus
p38 MAPK
-
 Gallus gallus
p38 MAPK
-
 Rattus norvegicus