Literature summary for 2.7.11.24 extracted from

Miller, A.L.; Webb, M.S.; Copik, A.J.; Wang, Y.; Johnson, B.H.; Kumar, R.; Thompson, E.B.
p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211 (2005), Mol. Endocrinol., 19, 1569-1583.

Search for more literature for 2.7.11.24

Activating Compound

Activating Compound	Comment	Organism	Structure
glucocorticoids	activate p38 MAPK, e.g. by induction of activating MKK3	Homo sapiens
additional information	p38 MAPk is activated through phosphorylation by MKK3, a MAPK kinase EC 2.7.11.25	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + human glucocorticoid receptor	Homo sapiens	specific phosphorylation at Ser211 by p38 MAPK, p38 MAPK is a mediator in glucocorticoid-induced apoptosis of lymphoid cells, interaction of MAPK and glucocorticoid pathways, overview	ADP + phosphorylated human glucocorticoid receptor	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozyme p38alpha MAPK	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	p38 MAPK is activated through phosphorylation by MKK3, a MAPK kinase EC 2.7.11.25	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
CCRF-CEM cell	cell line of a human with lymphoblastic leukemia	Homo sapiens	-
lymphoid cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + human glucocorticoid receptor	specific phosphorylation at Ser211 by p38 MAPK, p38 MAPK is a mediator in glucocorticoid-induced apoptosis of lymphoid cells, interaction of MAPK and glucocorticoid pathways, overview	Homo sapiens	ADP + phosphorylated human glucocorticoid receptor	-	?
ATP + human glucocorticoid receptor	specific phosphorylation at Ser211 by p38 MAPK	Homo sapiens	ADP + phosphorylated human glucocorticoid receptor	-	?

Synonyms

Synonyms	Comment	Organism
p38 MAPK	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.2	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)