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Literature summary for 2.7.11.24 extracted from

  • Edmunds, J.W.; Mahadevan, L.C.
    MAP kinases as structural adaptors and enzymatic activators in transcription complexes (2004), J. Cell Sci., 117, 3715-3723.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
12-O-tetradecanoylphorbol-13-acetate activates ERK1 and ERK2 Mammalia
MEF2D is crucial for activating phosphorylation of substrates within a transcription complex by BMK1, possibly by anchoring BMK1 to specific genes Mammalia
additional information AP1 and NF-kappaB recruit p38 MAPK to activate TBP Mammalia

Inhibitors

Inhibitors Comment Organism Structure
all-trans retinoic acid receptor ERK access to the substrate is regulated by the all-trans retinoic acid receptor, RAR Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Mammalia 5634
-
nucleus
-
Saccharomyces cerevisiae 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + AP1 Mammalia substrate of ERK1/2, ERK access to the substrate is regulated by the all-trans retinoic acid receptor, RAR ADP + phosphorylated AP1
-
?
ATP + DNA polymerase II Saccharomyces cerevisiae substrate of Hog1p ADP + phosphorylated DNA polymerase II
-
?
ATP + Hot1p Saccharomyces cerevisiae substrate of Hog1p, phosphorylation of Hot1p is not required for Hot1p-mediated gene expression ADP + phosphorylated Hot1p
-
?
ATP + TBP Mammalia substrate of p38 MAPK ADP + phosphorylated TBP
-
?
additional information Mammalia MAPK pathways overview, interaction of MAPKs and transcription factors, overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. ERK1 and ERK2 interact with AP1-complex, which is regulated via the all-trans retinoic acid receptor and TPA, overview ?
-
?
additional information Saccharomyces cerevisiae MAPK pathways overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. Hog1p, Hot1p, and Sko1p, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-
Saccharomyces cerevisiae
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the MAPKs are phosphorylated and activated by MAPKKs, EC 2.7.11.25, e.g. MKKs or MEKs, overview Mammalia
phosphoprotein the MAPKs are phosphorylated and activated by MAPKKs, EC 2.7.11.25, e.g. Ste7p, Pbs2p, or MKK1/2p, overview Saccharomyces cerevisiae

Source Tissue

Source Tissue Comment Organism Textmining
macrophage p38 MAPK Mammalia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + AP1 substrate of ERK1/2, ERK access to the substrate is regulated by the all-trans retinoic acid receptor, RAR Mammalia ADP + phosphorylated AP1
-
?
ATP + AP1 substrate of ERK1/2 Mammalia ADP + phosphorylated AP1
-
?
ATP + DNA polymerase II substrate of Hog1p Saccharomyces cerevisiae ADP + phosphorylated DNA polymerase II
-
?
ATP + Hot1p substrate of Hog1p Saccharomyces cerevisiae ADP + phosphorylated Hot1p
-
?
ATP + Hot1p substrate of Hog1p, phosphorylation of Hot1p is not required for Hot1p-mediated gene expression Saccharomyces cerevisiae ADP + phosphorylated Hot1p
-
?
ATP + TBP substrate of p38 MAPK Mammalia ADP + phosphorylated TBP
-
?
additional information MAPK pathways overview, interaction of MAPKs and transcription factors, overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. ERK1 and ERK2 interact with AP1-complex, which is regulated via the all-trans retinoic acid receptor and TPA, overview Mammalia ?
-
?
additional information MAPK pathways overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. Hog1p, Hot1p, and Sko1p, overview Saccharomyces cerevisiae ?
-
?
additional information transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes Mammalia ?
-
?
additional information transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes Saccharomyces cerevisiae ?
-
?

Subunits

Subunits Comment Organism
More transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes Mammalia
More transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
BMK1
-
Mammalia
ERK1
-
Mammalia
ERK2
-
Mammalia
Fus3p
-
Saccharomyces cerevisiae
Hog1p
-
Saccharomyces cerevisiae
JNK1
-
Mammalia
JNK2
-
Mammalia
JNK3
-
Mammalia
Kss1p
-
Saccharomyces cerevisiae
MAP kinase
-
Mammalia
MAP kinase
-
Saccharomyces cerevisiae
MAPK
-
Mammalia
MAPK
-
Saccharomyces cerevisiae
Mpk1p
-
Saccharomyces cerevisiae
p38alpha
-
Mammalia
p38beta
-
Mammalia
p38gamma
-
Mammalia
Smk1p
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mammalia
ATP
-
Saccharomyces cerevisiae