Activating Compound | Comment | Organism | Structure |
---|---|---|---|
12-O-tetradecanoylphorbol-13-acetate | activates ERK1 and ERK2 | Mammalia | |
MEF2D | is crucial for activating phosphorylation of substrates within a transcription complex by BMK1, possibly by anchoring BMK1 to specific genes | Mammalia | |
additional information | AP1 and NF-kappaB recruit p38 MAPK to activate TBP | Mammalia |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
all-trans retinoic acid receptor | ERK access to the substrate is regulated by the all-trans retinoic acid receptor, RAR | Mammalia |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mammalia | 5634 | - |
nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + AP1 | Mammalia | substrate of ERK1/2, ERK access to the substrate is regulated by the all-trans retinoic acid receptor, RAR | ADP + phosphorylated AP1 | - |
? | |
ATP + DNA polymerase II | Saccharomyces cerevisiae | substrate of Hog1p | ADP + phosphorylated DNA polymerase II | - |
? | |
ATP + Hot1p | Saccharomyces cerevisiae | substrate of Hog1p, phosphorylation of Hot1p is not required for Hot1p-mediated gene expression | ADP + phosphorylated Hot1p | - |
? | |
ATP + TBP | Mammalia | substrate of p38 MAPK | ADP + phosphorylated TBP | - |
? | |
additional information | Mammalia | MAPK pathways overview, interaction of MAPKs and transcription factors, overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. ERK1 and ERK2 interact with AP1-complex, which is regulated via the all-trans retinoic acid receptor and TPA, overview | ? | - |
? | |
additional information | Saccharomyces cerevisiae | MAPK pathways overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. Hog1p, Hot1p, and Sko1p, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the MAPKs are phosphorylated and activated by MAPKKs, EC 2.7.11.25, e.g. MKKs or MEKs, overview | Mammalia |
phosphoprotein | the MAPKs are phosphorylated and activated by MAPKKs, EC 2.7.11.25, e.g. Ste7p, Pbs2p, or MKK1/2p, overview | Saccharomyces cerevisiae |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | p38 MAPK | Mammalia | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + AP1 | substrate of ERK1/2, ERK access to the substrate is regulated by the all-trans retinoic acid receptor, RAR | Mammalia | ADP + phosphorylated AP1 | - |
? | |
ATP + AP1 | substrate of ERK1/2 | Mammalia | ADP + phosphorylated AP1 | - |
? | |
ATP + DNA polymerase II | substrate of Hog1p | Saccharomyces cerevisiae | ADP + phosphorylated DNA polymerase II | - |
? | |
ATP + Hot1p | substrate of Hog1p | Saccharomyces cerevisiae | ADP + phosphorylated Hot1p | - |
? | |
ATP + Hot1p | substrate of Hog1p, phosphorylation of Hot1p is not required for Hot1p-mediated gene expression | Saccharomyces cerevisiae | ADP + phosphorylated Hot1p | - |
? | |
ATP + TBP | substrate of p38 MAPK | Mammalia | ADP + phosphorylated TBP | - |
? | |
additional information | MAPK pathways overview, interaction of MAPKs and transcription factors, overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. ERK1 and ERK2 interact with AP1-complex, which is regulated via the all-trans retinoic acid receptor and TPA, overview | Mammalia | ? | - |
? | |
additional information | MAPK pathways overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. Hog1p, Hot1p, and Sko1p, overview | Saccharomyces cerevisiae | ? | - |
? | |
additional information | transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes | Mammalia | ? | - |
? | |
additional information | transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes | Saccharomyces cerevisiae | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes | Mammalia |
More | transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
BMK1 | - |
Mammalia |
ERK1 | - |
Mammalia |
ERK2 | - |
Mammalia |
Fus3p | - |
Saccharomyces cerevisiae |
Hog1p | - |
Saccharomyces cerevisiae |
JNK1 | - |
Mammalia |
JNK2 | - |
Mammalia |
JNK3 | - |
Mammalia |
Kss1p | - |
Saccharomyces cerevisiae |
MAP kinase | - |
Mammalia |
MAP kinase | - |
Saccharomyces cerevisiae |
MAPK | - |
Mammalia |
MAPK | - |
Saccharomyces cerevisiae |
Mpk1p | - |
Saccharomyces cerevisiae |
p38alpha | - |
Mammalia |
p38beta | - |
Mammalia |
p38gamma | - |
Mammalia |
Smk1p | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mammalia | |
ATP | - |
Saccharomyces cerevisiae |