Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.24 extracted from

  • Sater, A.K.; El-Hodiri, H.M.; Goswami, M.; Alexander, T.B.; Al-Sheikh, O.; Etkin, L.D.; Akif Uzman, J.
    Evidence for antagonism of BMP-4 signals by MAP kinase during Xenopus axis determination and neural specification (2003), Differentiation, 71, 434-444.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type MAP kinase and mutants in embryos by microinjection Xenopus laevis

Protein Variants

Protein Variants Comment Organism
additional information effects of overexpression of substrate Smad1 mutant S187A/S195A/S205A/S213A compared to overexpression of Smad1 wild-type, ventralizing of embryos, overview Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Smad1 Xenopus laevis the MAP kinase antagonizes Smad1 in signaling during development of axis and neural specification, Smad1 is involved in dorsal-ventral patterning in embryos ADP + phosphorylated Smad1
-
?

Organism

Organism UniProt Comment Textmining
Xenopus laevis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Xenopus laevis
-
neuron
-
Xenopus laevis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Smad1 the MAP kinase antagonizes Smad1 in signaling during development of axis and neural specification, Smad1 is involved in dorsal-ventral patterning in embryos Xenopus laevis ADP + phosphorylated Smad1
-
?
ATP + Smad1 phosphorylation by MAP kinase inhibits Smad1 and the BMP-4/Smad1 signaling pathway, phosphorylation sites are S187, S195, S205, and S213, activity with Smad1 mutant S187/S195/S205/S213, overview Xenopus laevis ADP + phosphorylated Smad1
-
?

Synonyms

Synonyms Comment Organism
MAP kinase
-
Xenopus laevis

Cofactor

Cofactor Comment Organism Structure
ATP
-
Xenopus laevis