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Literature summary for 2.7.11.24 extracted from
- Phosphatidylserine-specific receptor contributes to TGF-beta production in macrophages through a MAP kinase, ERK (2005), Biol. Pharm. Bull., 28, 1707-1710.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inhibition of the phosphatidylserine-receptor activates ERK and TGF-beta production in vivo | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| U0126 | specific inhibitor of ERK | Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | ERK, but not p38 and JNK, is involved in TGF-beta production in macrophages, the phosphatidylserine-receptor is involved in the ERK signaling pathway, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
male C3H/HeN mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| macrophage | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | ERK, but not p38 and JNK, is involved in TGF-beta production in macrophages, the phosphatidylserine-receptor is involved in the ERK signaling pathway, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ERK | - |
Mus musculus |
| MAP kinase | - |
Mus musculus |
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