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Literature summary for 2.7.11.24 extracted from

  • Johnson, L.N.; Noble, M.E.M.; Owen, D.J.
    Active and inactive protein kinases: structural basis for regulation (1996), Cell, 85, 149-158.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information phosphorylation at Thr183 and Tyr185 activates the enzyme Mammalia

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Mammalia
-
ADP + a phosphoprotein
-
?

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation at Thr183 and Tyr185 for activation Mammalia

Reaction

Reaction Comment Organism Reaction ID
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate catalytic aspartate residue Mammalia

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
Mammalia ADP + a phosphoprotein
-
?

Subunits

Subunits Comment Organism
More the enzyme has an open, active conformation and a closed, inactive conformation Mammalia

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mammalia