Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.23 extracted from

  • Payne, J.M.; Dahmus, M.E.
    Partial purification and characterization of two distinct protein kinases that differentially phosphorylate the carboxyl-terminal domain of RNA polymerase subunit IIa (1993), J. Biol. Chem., 268, 80-87.
    View publication on PubMed
Search for more literature for 2.7.11.23

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
 ATP 30°C, pH 7.9, kinase CTDK1 Homo sapiens
0.06
-
 ATP 30°C, pH 7.9, kinase CTDK2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] Homo sapiens
-
 ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens
two kinases: CDTK1 and CDTK2 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + casein phosphorylated at about 30% the rate of RNA-polymerase II subunit Homo sapiens ADP + phosphocasein
-
 ?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
-
 Homo sapiens ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
 ?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] kinase CTDK1: 33 mol phosphate per mol IIA-subunit Homo sapiens ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
 ?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] kinase CTDK1 almost exclusively phosphorylates Ser-residues Homo sapiens ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
 ?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] kinase CTDK2: 40-50 mol phosphate per mol IIA-subunit, i.e. 1 phosphate per heptapeptide repeat Homo sapiens ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
 ?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] phosphorylates predominantly Ser-residues Homo sapiens ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
 ?
dATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
-
 Homo sapiens dADP + ?
-
 ?
GTP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] kinase CTDK1, not kinase CTDK2 Homo sapiens GDP + ?
-
 ?