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Literature summary for 2.7.11.21 extracted from

  • Carmena, M.; Lombardia, M.O.; Ogawa, H.; Earnshaw, W.C.
    Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster (2014), Open Biology, 4, 140162.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster P52304
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Source Tissue

Source Tissue Comment Organism Textmining
larva
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Drosophila melanogaster
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neuroblast
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Drosophila melanogaster
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spermatocyte
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Drosophila melanogaster
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General Information

General Information Comment Organism
malfunction phenotype of different polo allele combinations compared to the effect of chemical inhibition. The chromosomal passenger complex is mislocalized in polo mutant meiosis. This defective CPC localization is independent of the degree of disruption of the spindle midzone, as visualized by staining for microtubules Drosophila melanogaster
physiological function polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis, e.g. in larval neuroblast mitoses, significant differences in the localization and activity of the chromosomal passenger complex in diploid tissues. Polo kinase is required for the correct localization and activity of the CPC at all stages of male meiosis as well as in larval neuroblast mitoses Drosophila melanogaster