Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | P52304 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
larva | - |
Drosophila melanogaster | - |
neuroblast | - |
Drosophila melanogaster | - |
spermatocyte | - |
Drosophila melanogaster | - |
General Information | Comment | Organism |
---|---|---|
malfunction | phenotype of different polo allele combinations compared to the effect of chemical inhibition. The chromosomal passenger complex is mislocalized in polo mutant meiosis. This defective CPC localization is independent of the degree of disruption of the spindle midzone, as visualized by staining for microtubules | Drosophila melanogaster |
physiological function | polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis, e.g. in larval neuroblast mitoses, significant differences in the localization and activity of the chromosomal passenger complex in diploid tissues. Polo kinase is required for the correct localization and activity of the CPC at all stages of male meiosis as well as in larval neuroblast mitoses | Drosophila melanogaster |