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Literature summary for 2.7.11.21 extracted from

  • Johmura, Y.; Soung, N.K.; Park, J.E.; Yu, L.R.; Zhou, M.; Bang, J.K.; Kim, B.Y.; Veenstra, T.D.; Erikson, R.L.; Lee, K.S.
    Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1 (2011), Proc. Natl. Acad. Sci. USA, 108, 11446-11451.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.21

Localization

Localization Comment Organism GeneOntology No. Textmining
mitotic spindle
-
 Homo sapiens 72686
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Hice1 subunit of Augmin complex Homo sapiens via the formation of the Nedd1-Plk1 complex and subsequent Augmin phosphorylation, Plk1 regulates spindle microtubule-based microtubule nucleation to accomplish normal bipolar spindle formation and mitotic progression ADP + phosphorylated Hice1 subunit of Augmin complex
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Hice1 subunit of Augmin complex
-
 Homo sapiens ADP + phosphorylated Hice1 subunit of Augmin complex
-
 ?
ATP + Hice1 subunit of Augmin complex via the formation of the Nedd1-Plk1 complex and subsequent Augmin phosphorylation, Plk1 regulates spindle microtubule-based microtubule nucleation to accomplish normal bipolar spindle formation and mitotic progression Homo sapiens ADP + phosphorylated Hice1 subunit of Augmin complex
-
 ?

Synonyms

Synonyms Comment Organism
Plk1
-
 Homo sapiens
Polo-like kinase 1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function via the formation of the Nedd1-Plk1 complex and subsequent Augmin phosphorylation, Plk1 regulates spindle microtubule-based microtubule nucleation to accomplish normal bipolar spindle formation and mitotic progression Homo sapiens