Any feedback?
Literature summary for 2.7.11.21 extracted from
- Modulating polo-like kinase 1 as a means for cancer chemoprevention (2010), Pharm. Res., 27, 989-998.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| aurora A | Plk1 activity is increased upon phosphorylation at threonine-210 by Aurora A in conjunction with Bora | Mammalia | |
| Bora | Plk1 activity is increased upon phosphorylation at threonine-210 by Aurora A in conjunction with Bora | Mammalia |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | Plk1 may be a useful target for cancer chemoprevention | Mammalia |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| genistein | decreases Plk1 expression | Mammalia |  |
| indirubin | decreases Plk1 expression | Mammalia | |
| morin | enzymatic inhibitor | Mammalia | |
| purpurogallin | polo box inhibitor | Mammalia | |
| quercetin | enzymatic inhibitor | Mammalia | |
| scytonemin | enzymatic inhibitor | Mammalia | |
| silibinin | decreases Plk1 expression | Mammalia | |
| staurosporine | enzymatic inhibitor | Mammalia | |
| thymoquinone | polo box inhibitor | Mammalia | |
| trichostatin A | decreases Plk1 expression | Mammalia | |
| Vanillin | decreases Plk1 expression | Mammalia | |
| Wortmannin | enzymatic inhibitor | Mammalia | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Mammalia | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mammalia | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Mammalia |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
Mammalia | ADP + a phosphoprotein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Plk1 | - |
Mammalia |
| Polo-like kinase 1 | - |
Mammalia |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mammalia | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000024 | - |
- |
Mammalia | Wortmannin | |
| 0.0008 | - |
- |
Mammalia | staurosporine | |
| 0.002 | - |
- |
Mammalia | scytonemin | |
| 0.0126 | - |
- |
Mammalia | morin | |
| 0.064 | - |
- |
Mammalia | quercetin | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mammalia | decline upon mitotic exit into G1 | down |
| Mammalia | Plk1 mRNA, protein and activity levels begin to rise in S-phase, peaking at the G2/M transition, over-expressed in a variety of cancers | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Plk1 plays several crucial roles in cell cycle progression and cell division | Mammalia |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
