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Literature summary for 2.7.11.21 extracted from

  • Archambault, V.; Glover, D.
    Polo-like kinases: Conservation and divergence in their functions and regulation (2009), Nat. Rev. Mol. Cell Biol., 10, 265-275.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information activated by phosphorylation Drosophila melanogaster
additional information activated by phosphorylation Homo sapiens
additional information activated by phosphorylation Saccharomyces cerevisiae
additional information activated by phosphorylation Xenopus laevis
additional information activated by phosphorylation Saccharomyces pombe

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Drosophila melanogaster
-
ADP + a phosphoprotein
-
?
ATP + a protein Homo sapiens
-
ADP + a phosphoprotein
-
?
ATP + a protein Saccharomyces cerevisiae
-
ADP + a phosphoprotein
-
?
ATP + a protein Xenopus laevis
-
ADP + a phosphoprotein
-
?
ATP + a protein Saccharomyces pombe
-
ADP + a phosphoprotein
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-
Saccharomyces pombe
-
-
-
Xenopus laevis
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
Drosophila melanogaster
phosphoprotein
-
Homo sapiens
phosphoprotein
-
Saccharomyces cerevisiae
phosphoprotein
-
Xenopus laevis
phosphoprotein
-
Saccharomyces pombe

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
Drosophila melanogaster ADP + a phosphoprotein
-
?
ATP + a protein
-
Homo sapiens ADP + a phosphoprotein
-
?
ATP + a protein
-
Saccharomyces cerevisiae ADP + a phosphoprotein
-
?
ATP + a protein
-
Xenopus laevis ADP + a phosphoprotein
-
?
ATP + a protein
-
Saccharomyces pombe ADP + a phosphoprotein
-
?

Synonyms

Synonyms Comment Organism
Cdc5
-
Saccharomyces cerevisiae
PLK
-
Drosophila melanogaster
PLK
-
Homo sapiens
Plo1
-
Saccharomyces pombe
Plx1
-
Xenopus laevis
polo-like kinase
-
Drosophila melanogaster
polo-like kinase
-
Homo sapiens
polo-like kinase
-
Saccharomyces cerevisiae
polo-like kinase
-
Xenopus laevis
polo-like kinase
-
Saccharomyces pombe

Cofactor

Cofactor Comment Organism Structure
ATP
-
Drosophila melanogaster
ATP
-
Homo sapiens
ATP
-
Saccharomyces cerevisiae
ATP
-
Xenopus laevis
ATP
-
Saccharomyces pombe

Expression

Organism Comment Expression
Homo sapiens up-regulated in many tumors up

General Information

General Information Comment Organism
physiological function Plks are potent regulators of M phase, their roles in mitotic entry, spindle pole functions and cytokinesis are broadly conserved Drosophila melanogaster
physiological function Plks are potent regulators of M phase, their roles in mitotic entry, spindle pole functions and cytokinesis are broadly conserved Homo sapiens
physiological function Plks are potent regulators of M phase, their roles in mitotic entry, spindle pole functions and cytokinesis are broadly conserved Saccharomyces cerevisiae
physiological function Plks are potent regulators of M phase, their roles in mitotic entry, spindle pole functions and cytokinesis are broadly conserved Xenopus laevis
physiological function Plks are potent regulators of M phase, their roles in mitotic entry, spindle pole functions and cytokinesis are broadly conserved Saccharomyces pombe