Application | Comment | Organism |
---|---|---|
medicine | PLK1 is a promising target for the molecular therapy of anaplastic thyroid carcinoma, ATC | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-((R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-3-methoxy-N-(1-methyl-piperidin-4-yl)-benzamide | BI 2536 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P53350 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
8505C cell | anaplastic thyroid carcinoma cell line | Homo sapiens | - |
ACT-1 cell | anaplastic thyroid carcinoma cell line | Homo sapiens | - |
CAL-62 cell | anaplastic thyroid carcinoma cell line | Homo sapiens | - |
OCUT-1 cell | anaplastic thyroid carcinoma cell line | Homo sapiens | - |
SW-1736 cell | anaplastic thyroid carcinoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Plk1 | - |
Homo sapiens |
Polo-like kinase 1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
activity assay | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
activity assay | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000083 | - |
- |
Homo sapiens | 4-((R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-3-methoxy-N-(1-methyl-piperidin-4-yl)-benzamide |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | PLK1 is highly expressed in anaplastic thyroid carcinoma, ATC | up |
General Information | Comment | Organism |
---|---|---|
physiological function | PLK1 is a key regulator of multiple steps during mitotic progression | Homo sapiens |