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Literature summary for 2.7.11.21 extracted from
- Polo-like kinase 1 as a new target for non-Hodgkins lymphoma treatment (2008), Oncology, 74, 96-103.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in the study Plk1 is detected in 63.6% of Non-Hodgkin's Lymphoma cases and overexpression is positively linked to systemic symptom, elevated LDH level and higher IDI scores, Plk1 may be a new target in NHL therapy | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| siRNA targeted against Plk1 gene is cloned into pEGFP-H1 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| siRNA | - |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + protein | Homo sapiens | - |
ADP + phosphoprotein | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P53350 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| diffuse large B-cell lymphoma cell | - |
Homo sapiens | - |
| JURKAT cell | - |
Homo sapiens | - |
| lymphoma cell | peripheral T cell lymphoma | Homo sapiens | - |
| RAJI cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + protein | - |
Homo sapiens | ADP + phosphoprotein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Polo-like kinase 1 | - |
Homo sapiens |
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