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Literature summary for 2.7.11.21 extracted from
- Finding Plk3 (2007), Cell Cycle, 6, 1314-1318.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | only one polo kinase found, is a master mitotic regulator, involved in the regulation of mitotic entry, the metaphase to anaphase transition, mitotic exit and cytokinesis | Drosophila melanogaster |
| additional information | only one polo kinase found, is a master mitotic regulator, involved in the regulation of mitotic entry, the metaphase to anaphase transition, mitotic exit and cytokinesis | Saccharomyces cerevisiae |
| additional information | Plk1 functions during mitosis and cytokinesis | Homo sapiens |
| additional information | Plk2 is expressed earlier in the cell cycle | Homo sapiens |
| additional information | Plk3 is expressed earlier in the cell cycle, regulates entry into S phase, attenuates cyclin E expression through a post transcriptional mechanism, it must be a critical regulator of G1 events | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ONO1910 | does not significantly impacting Plk3 activity in vitro; inhibits Plk1 activity without significantly impacting Plk3 activity in vitro | Homo sapiens |  |
| RNAi | induces Plk3 depletion, which causes a large fraction of cells to become quiescent, Plk3-depleted cells appear to pass through mitosis normally and complete cell division, but failed to reenter the cell cycle | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| centrosome | Plk1 expressed during G2 and mitosis | Homo sapiens | 5813 | - |
| kinetochore | Plk1 expressed during G2 and mitosis | Homo sapiens | 776 | - |
| additional information | Plk1 is expressed during G2 and mitosis at the midbody | Homo sapiens | - |
- |
| nucleolus | Plk3, as long as the nucleolus is intact, and is undetectable during mitosis | Homo sapiens | 5730 | - |
| spindle | Plk1 is expressed during G2 and mitosis at the spindle pole and spindle midzone | Homo sapiens | 5819 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
| Homo sapiens | P53350 | - |
- |
| Homo sapiens | Q9H4B4 | - |
- |
| Homo sapiens | Q9NYY3 | - |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MCF-10A cell | - |
Homo sapiens | - |
| MCF-10A cell | Plk3 accumulates by serum starvation, at a point in the cell cycle commonly referred to as G0 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Cdc25A | - |
Homo sapiens | ADP + phosphorylated Cdc25A | - |
? | |
| ATP + p53 | Plk1 apparently phosphorylates other residues than Plk3 | Homo sapiens | ADP + phosphorylated p53 | - |
? | |
| ATP + p53 | Plk3 apparently phosphorylates other residues than Plk1 | Homo sapiens | ADP + phosphorylated p53 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Plk1 | - |
Homo sapiens |
| Plk2 | - |
Homo sapiens |
| Plk3 | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000009 | - |
- |
Homo sapiens | ONO1910 | |
| 0.00026 | - |
Plk2 | Homo sapiens | ONO1910 | |
| 0.01 | - |
- |
Homo sapiens | ONO1910 | |
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