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Literature summary for 2.7.11.21 extracted from

  • Glover, D.M.
    Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles (2005), Oncogene, 24, 230-237.
    View publication on PubMed
Search for more literature for 2.7.11.21

Cloned(Commentary)

Cloned (Comment) Organism
developmental expression analysis of the highly conserved enzyme Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
additional information mutant phenotype analysis Drosophila melanogaster

General Stability

General Stability Organism
association with Hsp90 at the centrosome stabilizes the enzyme Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
centrosome associated with Hsp90 Drosophila melanogaster 5813
-
cytoplasm
-
 Drosophila melanogaster 5737
-
kinetochore
-
 Drosophila melanogaster 776
-
spindle mid zone of the central spindle Drosophila melanogaster 5819
-
spindle pole
-
 Drosophila melanogaster 922
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 85kDa microtubule-associated protein Drosophila melanogaster protein is released from microtubules after phosphorylation ADP + phosphorylated 85kDa microtubule-associated protein
-
 ?
ATP + abnormal spindle pole protein Drosophila melanogaster i.e. abnormal spindle pole protein, activation of abnormal spindle pole protein by phosphorylation ADP + phosphorylated abnormal spindle pole protein
-
 ?
ATP + dephospho-beta-tubulin Drosophila melanogaster the enzyme is required for beta-tubulin recruitment to the centrosome ADP + phosphorylated beta-tubulin
-
 ?
additional information Drosophila melanogaster the enzyme is a mitotic kinase and is required for centrosome maturation at mitotic M-phase entry in order to recruit the gamma-tubulin ring complex and activate abnormal spindle pole protein, Asp, the enzyme is involved in mitotic networks and cytokinesis, e.g. in spermatogenesis, overview, functional modeling of polo kinase in mitotic phases ?
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Drosophila melanogaster
-
larva
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 85kDa microtubule-associated protein
-
 Drosophila melanogaster ADP + phosphorylated 85kDa microtubule-associated protein
-
 ?
ATP + 85kDa microtubule-associated protein protein is released from microtubules after phosphorylation Drosophila melanogaster ADP + phosphorylated 85kDa microtubule-associated protein
-
 ?
ATP + abnormal spindle pole protein
-
 Drosophila melanogaster ADP + phosphorylated abnormal spindle pole protein
-
 ?
ATP + abnormal spindle pole protein i.e. abnormal spindle pole protein, activation of abnormal spindle pole protein by phosphorylation Drosophila melanogaster ADP + phosphorylated abnormal spindle pole protein
-
 ?
ATP + dephospho-beta-tubulin
-
 Drosophila melanogaster ADP + phosphorylated beta-tubulin
-
 ?
ATP + dephospho-beta-tubulin the enzyme is required for beta-tubulin recruitment to the centrosome Drosophila melanogaster ADP + phosphorylated beta-tubulin
-
 ?
additional information the enzyme is a mitotic kinase and is required for centrosome maturation at mitotic M-phase entry in order to recruit the gamma-tubulin ring complex and activate abnormal spindle pole protein, Asp, the enzyme is involved in mitotic networks and cytokinesis, e.g. in spermatogenesis, overview, functional modeling of polo kinase in mitotic phases Drosophila melanogaster ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Drosophila melanogaster