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Literature summary for 2.7.11.21 extracted from

  • Sumara, I.; Gimenez-Abian, J.F.; Gerlich, D.; Hirota, T.; Kraft, C.; de la Torre, C.; Ellenberg, J.; Peters, J.M.
    Roles of polo-like kinase 1 in the assembly of functional mitotic spindles (2004), Curr. Biol., 14, 1712-1722.
    View publication on PubMed
Search for more literature for 2.7.11.21

Inhibitors

Inhibitors Comment Organism Structure
additional information Plk1 depletion in HeLa Plk RNAi cells by Aurora B inhibitor hesperadin, enzyme depletion delays entry into mitosis and arrest in prometaphase activating the spindle checkpoint Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
centrosome
-
 Homo sapiens 5813
-
kinetochore
-
 Homo sapiens 776
-
nucleoplasm nucleocytoplasmic space of mitotic cells Homo sapiens 5654
-
spindle mid Homo sapiens 5819
-
spindle pole
-
 Homo sapiens 922
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Plk1 is involved in regulating centrosome maturation, mitotic entry, sister chromatid cohesion, the anaphase-promoting complex/cyclosome, and cytokinesis, as well as in chromosome orientation, detailed overview of physiological functions of the enzyme ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Plk1 is involved in regulating centrosome maturation, mitotic entry, sister chromatid cohesion, the anaphase-promoting complex/cyclosome, and cytokinesis, as well as in chromosome orientation, detailed overview of physiological functions of the enzyme Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Plk1
-
 Homo sapiens
Polo-like kinase 1
-
 Homo sapiens