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Literature summary for 2.7.11.20 extracted from

  • Piserchio, A.; Will, N.; Giles, D.H.; Hajredini, F.; Dalby, K.N.; Ghose, R.
    Solution structure of the carboxy-terminal tandem repeat domain of eukaryotic elongation factor 2 kinase and its role in substrate recognition (2019), J. Mol. Biol., 431, 2700-2717 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.20

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
the C-terminal fragment of the enzyme, eEF-2K562 725, is expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the C-terminal fragment of the enzyme, eEF-2K562-725, is able to inhibit the phosphorylation of eukaryotic elongation factor 2 by full-length enzyme in trans Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [eukaryotic elongation factor 2] Homo sapiens
-
 ADP + [eukaryotic elongation factor 2] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00418
-
-

Purification (Commentary)

Purification (Comment) Organism
HiTrap Q column chromatography, and Superdex 75 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [eukaryotic elongation factor 2]
-
 Homo sapiens ADP + [eukaryotic elongation factor 2] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
EEF-2K
-
 Homo sapiens
eukaryotic elongation factor 2 kinase
-
 Homo sapiens