Application | Comment | Organism |
---|---|---|
medicine | high levels of enzyme expression are associated with invasive carcinoma and metastatic tumors. Inhibiting the enzyme may help prevent cancer cell mobility and metastasis. The enzyme is a potential therapeutic target for preventing tumor metastasis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
A-484954 | - |
Homo sapiens | |
JAN-384 | - |
Homo sapiens | |
NH125 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [eukaryotic elongation factor 2] | Homo sapiens | - |
ADP + [eukaryotic elongation factor 2] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00418 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
breast cancer cell | - |
Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [eukaryotic elongation factor 2] | - |
Homo sapiens | ADP + [eukaryotic elongation factor 2] phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
eEF2 kinase | - |
Homo sapiens |
eEF2K | - |
Homo sapiens |
eukaryotic elongation factor 2 kinase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | knocking down or inhibiting the enzyme in cancer cells impairs migration and invasion of cancer cells | Homo sapiens |
physiological function | the enzyme controls the translation of mRNAs encoding proteins involving in cell migration | Homo sapiens |