Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [eukaryotic elongation factor 2] | Rattus norvegicus | - |
ADP + [eukaryotic elongation factor 2] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P70531 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiomyoblast | - |
Rattus norvegicus | - |
H9c2 cell | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [eukaryotic elongation factor 2] | - |
Rattus norvegicus | ADP + [eukaryotic elongation factor 2] phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
eEF2 kinase | - |
Rattus norvegicus |
eEF2K | - |
Rattus norvegicus |
eukaryotic elongation factor 2 kinase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme gene knockdown significantly augments glucose deprivation-induced cleavage of caspase-3 and apoptotic nuclear condensation. In contrast, enzyme gene knockdown significantly inhibits glucose deprivation-induced increase of microtubule-associated protein 1 light chain 3-II to -I ratio and autophagosome formation. Enzyme gene knockdown significantly inhibits GD-induced phosphorylation of adenosine monophosphate-activated protein kinase alpha and its downstream substrate, unc-51 like autophagy activating kinase 1 | Rattus norvegicus |
physiological function | the enzyme mediates the inhibition of cardiomyocyte death under glucose deprivation condition | Rattus norvegicus |