Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | required | Mus musculus | |
additional information | inhibition of eEF2 phosphorylation leads to increased activity of its upstream regulators AMP-activated protein kinase and eEF2 kinase, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
compound C | AMPK inhibitor compound C blocks eEF2K and eEF2 phosphorylation | Mus musculus | |
lopinavir | i.e. LPV, increases the phosphorylation of eEF2 kinase on Ser366 reducing its activity, LPV affects eEF2 activity via an AMPK-eEF2K dependent pathway, overview | Mus musculus | |
additional information | rottlerin suppresses eEF2K, but not eEF2 phosphorylation in myocytes | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Mus musculus | |
Mg2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [eukaryotic translation elongation factor 2] | Mus musculus | inhibition of eEF2 phosphorylation leads to increased activity of its upstream regulators AMP-activated protein kinase, AMPK, and eEF2 kinase, eEF2K, regulation, overview | ADP + [eukaryotic translation elongation factor 2] phosphate | - |
? | |
additional information | Mus musculus | rottlerin suppresses eEF2K, but not eEF2 phosphorylation in myocytes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of eEF2K can either inhibit or enhance the activity of its downstream substrate, depending on the site of phosphorylation and the type of stimul, lopinavir increases the phosphorylation of eEF2 kinase on Ser366 reducing its activity, LPV affects eEF2 activity via an AMPK-eEF2K dependent pathway, overview | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | murine myoblasts | Mus musculus | - |
myocyte | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [eukaryotic translation elongation factor 2] | inhibition of eEF2 phosphorylation leads to increased activity of its upstream regulators AMP-activated protein kinase, AMPK, and eEF2 kinase, eEF2K, regulation, overview | Mus musculus | ADP + [eukaryotic translation elongation factor 2] phosphate | - |
? | |
ATP + [eukaryotic translation elongation factor 2] | i.e. eEF2, both AMP-activated protein kinase, AMPK, and eEF2 kinase, eEF2K, phosphorylate eEF2, thus two distinct paths lead to eEF2 phosphorylation, overview | Mus musculus | ADP + [eukaryotic translation elongation factor 2] phosphate | - |
? | |
additional information | rottlerin suppresses eEF2K, but not eEF2 phosphorylation in myocytes | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
eEF2 kinase | - |
Mus musculus |
eEF2K | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |