Literature summary for 2.7.11.20 extracted from

Boyce, M.; Py, B.F.; Ryazanov, A.G.; Minden, J.S.; Long, K.; Ma, D.; Yuan, J.
A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death (2008), Cell Death Differ., 15, 589-599.

Search for more literature for 2.7.11.20

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of gene eEF-2K deletion mutants, phenotype, overview	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Mus musculus	5783	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [eukaryotic translation elongation factor 2]	Mus musculus	the enzyme is involved in eukaryotic elongation factor 2 kinase in ER stress-induced signaling and cell death by inducing stress factors, regulation cascade, overview	ADP + [eukaryotic translation elongation factor 2] phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O08796	gene eEF-2K	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	-	Mus musculus	-
MEF cell	primary mouse embryonic fibroblasts	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [eukaryotic translation elongation factor 2]	phosphorylation at Thr56	Mus musculus	ADP + [eukaryotic translation elongation factor 2] phosphate	-	?
ATP + [eukaryotic translation elongation factor 2]	the enzyme is involved in eukaryotic elongation factor 2 kinase in ER stress-induced signaling and cell death by inducing stress factors, regulation cascade, overview	Mus musculus	ADP + [eukaryotic translation elongation factor 2] phosphate	-	?

Synonyms

Synonyms	Comment	Organism
EEF-2K	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)