Application | Comment | Organism |
---|---|---|
medicine | plays a regulatory role in the autophagic process in tumor cells and may promote cancer cell survival under conditions of nutrient deprivation, eEF-2 kinase activation may be a part of a survival mechanism in glioblastoma | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
siRNA | knockdown of eEF-2 kinase and inhibition of autophagy in several cell types | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | when deprived of nutrients, the activity of eEF-2 kinase is rapidly increased | Homo sapiens | - |
T-98G cell | when deprived of nutrients, the activity of eEF-2 kinase is rapidly increased | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 2] | - |
Homo sapiens | ADP + [elongation factor 2]phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ca2+/calmodulin-dependent kinase III | - |
Homo sapiens |
eEF-2 kinase | - |
Homo sapiens |