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Literature summary for 2.7.11.20 extracted from

  • Ren, H.; Tai, S.K.; Khuri, F.; Chu, Z.; Mao, L.
    Farnesyltransferase inhibitor SCH66336 induces rapid phosphorylation of eukaryotic translation elongation factor 2 in head and neck squamous cell carcinoma cells (2005), Cancer Res., 65, 5841-5847.
    View publication on PubMed
Search for more literature for 2.7.11.20

Activating Compound

Activating Compound Comment Organism Structure
phosphorylated MEK activates the enzyme Homo sapiens
phosphorylated p70S6K activates the enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [elongation translation factor 2] Homo sapiens
-
 ADP + [elongation translation factor 2]phosphate
-
 ?
additional information Homo sapiens SCH66336, a farnesyltransferase inhibitor, induces rapid phosphorylation and inhibition of eukaryotic translation elongation factor 2 in head and squamous cell carcinoma cells leading to growth inhibition in the cancer cells, the inhibitor functions independently of the signaling cascade involving the eEF2 kinase and its activators phosphorylated p70S6K and phosphorylated MEK ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-1186 cell cancer cell line Homo sapiens
-
MDA-886 cell cancer cell line Homo sapiens
-
squamous cell carcinoma cell cell lines of head and neck cancer Homo sapiens
-
TR-146 cell cancer cell line Homo sapiens
-
UMSCC-14B cell cancer cell line Homo sapiens
-
UMSCC-17B cell cancer cell line Homo sapiens
-
UMSCC-21A cell cancer cell line Homo sapiens
-
UMSCC-22A cell cancer cell line Homo sapiens
-
UMSCC-38 cell cancer cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [elongation translation factor 2]
-
 Homo sapiens ADP + [elongation translation factor 2]phosphate
-
 ?
additional information SCH66336, a farnesyltransferase inhibitor, induces rapid phosphorylation and inhibition of eukaryotic translation elongation factor 2 in head and squamous cell carcinoma cells leading to growth inhibition in the cancer cells, the inhibitor functions independently of the signaling cascade involving the eEF2 kinase and its activators phosphorylated p70S6K and phosphorylated MEK Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
eEF2 kinase
-
 Homo sapiens
eEF2K
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens