Literature summary for 2.7.11.2 extracted from

Lee, S.J.; Jeong, J.Y.; Oh, C.J.; Park, S.; Kim, J.Y.; Kim, H.J.; Doo Kim, N.; Choi, Y.K.; Do, J.Y.; Go, Y.; Ha, C.M.; Ha, C.M.; Choi, J.Y.; Huh, S.; Ho Jeoung, N.; Lee, K.U.; Choi, H.S.; Wang, Y.; Park, K.G.; Harris, R.A.; Lee, I.K.
Pyruvate dehydrogenase kinase 4 promotes vascular calcification via SMAD1/5/8 phosphorylation (2015), Sci. Rep., 5, 16577.

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Application

Application	Comment	Organism
medicine	the enzyme is a therapeutic target for vascular calcification	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Dichloroacetate	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + SMAD1/5/8 protein	Homo sapiens	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16654	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
vascular smooth muscle cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + SMAD1/5/8 protein	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
PDK4	-	Homo sapiens
pyruvate dehydrogenase kinase 4	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	enzyme inhibition ameliorates the calcification in phosphate-treated vascular smooth muscle cells and aortic rings	Homo sapiens
physiological function	the enzyme augments the osteogenic differentiation of vascular smooth muscle cells by phosphorylating SMAD1/5/8 via direct interaction, which enhances BMP2 signaling	Homo sapiens

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Release 2023.1 (January 2023)