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Literature summary for 2.7.11.2 extracted from

  • Holness, M.J.; Bulmer, K.; Smith, N.D.; Sugden, M.C.
    Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone (2003), Biochem. J., 369, 687-695.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Lipid enhance expression of hepatic isozyme PDK2 during high-fat feeding Rattus norvegicus
additional information during hyperthyroidism, the expression of hepatic isozymes PDK2 and PDK4 is increased Rattus norvegicus
additional information starvation increases expression of isozyme PDK4 Rattus norvegicus
peroxisome proliferator-activated receptor-alpha involved in mechanism to enhance expression of isozyme PDK4, but not isozyme PDK2, during starvation Rattus norvegicus
WY-14,643 activator of peroxisome proliferator-activated receptor-alpha Rattus norvegicus
WY-14,643 in liver, specifically increases PDK4 expression Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [pyruvate dehydrogenase (lipoamide)] Rattus norvegicus tissue-specific regulation of the pyruvate dehydrogenase complex in order to adjust glucose consumption ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir
ATP + [pyruvate dehydrogenase (lipoamide)] Rattus norvegicus catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir
ATP + [pyruvate dehydrogenase (lipoamide)] Rattus norvegicus high-fat feeding increases the expression of isozyme PDK2, but not of PDK4, hyperthyroidism increases the expression of both isozymes, physiological implications ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
female Wistar rats
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Rattus norvegicus
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isozymes PDK2 and PDK4
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Source Tissue

Source Tissue Comment Organism Textmining
liver a complex signalling mechanism mediates the regulation of the isozymes PDK2 and PDK4 in response to the feeding status of the organism, overview Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [pyruvate dehydrogenase (lipoamide)]
-
Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir
ATP + [pyruvate dehydrogenase (lipoamide)] tissue-specific regulation of the pyruvate dehydrogenase complex in order to adjust glucose consumption Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir
ATP + [pyruvate dehydrogenase (lipoamide)] catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir
ATP + [pyruvate dehydrogenase (lipoamide)] high-fat feeding increases the expression of isozyme PDK2, but not of PDK4, hyperthyroidism increases the expression of both isozymes, physiological implications Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir

Synonyms

Synonyms Comment Organism
PDK
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Rattus norvegicus