Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6'-bromoindirubin-3'-oxime | - |
Oryctolagus cuniculus | |
6,5-dichloroindirubin | - |
Oryctolagus cuniculus | |
6,5-dichloroindirubin-3'-acetoxime | - |
Oryctolagus cuniculus | |
6,5-dichloroindirubin-3'-oxime | - |
Oryctolagus cuniculus | |
6,6'-dibromoindirubin-3'-oxime | - |
Oryctolagus cuniculus | |
6-bromo-5-methylindirubin | - |
Oryctolagus cuniculus | |
6-bromo-5-methylindirubin-3'-acetoxime | - |
Oryctolagus cuniculus | |
6-bromo-5-nitroindirubin | - |
Oryctolagus cuniculus | |
6-bromo-5-nitroindirubin-3'-acetoxime | - |
Oryctolagus cuniculus | |
6-bromo-5-nitroindirubin-3'-oxime | - |
Oryctolagus cuniculus | |
6-bromo-N-methylindirubin | - |
Oryctolagus cuniculus | |
6-bromo-N-methylindirubin-3'-acetoxime | - |
Oryctolagus cuniculus | |
6-bromoindirubin | - |
Oryctolagus cuniculus | |
6-bromoindirubin-3'-acetoxime | - |
Oryctolagus cuniculus | |
6-bromoindirubin-3'-oxime | - |
Oryctolagus cuniculus | |
6-chloroindirubin | - |
Oryctolagus cuniculus | |
6-chloroindirubin-3'-oxime | - |
Oryctolagus cuniculus | |
6-fluoroindirubin | - |
Oryctolagus cuniculus | |
6-fluoroindirubin-3'-oxime | - |
Oryctolagus cuniculus | |
6-iodoindirubin-3'-oxime | - |
Oryctolagus cuniculus | |
6-methoxindirubin-3'-acetoxime | - |
Oryctolagus cuniculus | |
6-methoxindirubin-3'-oxime | - |
Oryctolagus cuniculus | |
6-vinylindirubin | - |
Oryctolagus cuniculus | |
6-vinylindirubin-3'-acetoxime | - |
Oryctolagus cuniculus | |
6-vinylindirubin-3'-oxime | - |
Oryctolagus cuniculus | |
7-bromo-N-methylindirubin | - |
Oryctolagus cuniculus | |
7-bromo-N-methylindirubin-3'-acetoxime | - |
Oryctolagus cuniculus | |
7-bromo-N-methylindirubin-3'-methoxime | - |
Oryctolagus cuniculus | |
7-bromo-N-methylindirubin-3'-oxime | - |
Oryctolagus cuniculus | |
7-bromoindirubin | - |
Oryctolagus cuniculus | |
7-bromoindirubin-3'-acetoxime | - |
Oryctolagus cuniculus | |
7-bromoindirubin-3'-methoxime | - |
Oryctolagus cuniculus | |
7-bromoindirubin-3'-oxime | - |
Oryctolagus cuniculus | |
7-carboxylindirubin | - |
Oryctolagus cuniculus | |
indirubin | - |
Oryctolagus cuniculus | |
indirubin 3'-oxime | - |
Oryctolagus cuniculus | |
indirubin-3'-acetoxime | - |
Oryctolagus cuniculus | |
indirubin-3'-methoxime | - |
Oryctolagus cuniculus | |
additional information | evaluation of indirubin analogues as phosphorylase kinase inhibitors, structure-activity relationship analysis, docking, overview. The inhibitory effects arises from binding at the kinase domain, i.e. gamma-subunit | Oryctolagus cuniculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Oryctolagus cuniculus | |
Mg2+ | required | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + glycogen phosphorylase b | Oryctolagus cuniculus | - |
2 ADP + glycogen phosphorylase a | - |
? | |
2 ATP + glycogen phosphorylase b | Oryctolagus cuniculus New Zealand White | - |
2 ADP + glycogen phosphorylase a | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Oryctolagus cuniculus New Zealand White | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + glycogen phosphorylase b | - |
Oryctolagus cuniculus | 2 ADP + glycogen phosphorylase a | - |
? | |
2 ATP + glycogen phosphorylase b | - |
Oryctolagus cuniculus New Zealand White | 2 ADP + glycogen phosphorylase a | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PhK | - |
Oryctolagus cuniculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Oryctolagus cuniculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00017 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | indirubin-3'-acetoxime | |
0.0002 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6,5-dichloroindirubin-3'-oxime | |
0.00021 | - |
pH not spefified in the publication, 30°C | Oryctolagus cuniculus | indirubin 3'-oxime | |
0.00022 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-fluoroindirubin-3'-oxime | |
0.00023 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-chloroindirubin-3'-oxime | |
0.00029 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6'-bromoindirubin-3'-oxime | |
0.00033 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-bromoindirubin-3'-acetoxime | |
0.00033 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-iodoindirubin-3'-oxime | |
0.00034 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-bromoindirubin-3'-oxime | |
0.00034 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | indirubin-3'-methoxime | |
0.00036 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-bromo-5-methylindirubin-3'-acetoxime | |
0.00054 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-vinylindirubin-3'-acetoxime | |
0.00055 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-vinylindirubin-3'-oxime | |
0.0007 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-methoxindirubin-3'-oxime | |
0.00082 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6,5-dichloroindirubin-3'-acetoxime | |
0.001 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-bromo-5-nitroindirubin-3'-oxime | |
0.00113 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-methoxindirubin-3'-acetoxime | |
0.0012 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-bromo-5-nitroindirubin-3'-acetoxime | |
0.0018 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 7-bromoindirubin-3'-oxime | |
0.00233 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6,6'-dibromoindirubin-3'-oxime | |
0.01 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 7-bromoindirubin-3'-acetoxime | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-bromo-5-methylindirubin | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-bromo-5-nitroindirubin | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-bromo-N-methylindirubin | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-bromo-N-methylindirubin-3'-acetoxime | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-bromoindirubin | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-chloroindirubin | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-fluoroindirubin | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6-vinylindirubin | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 6,5-dichloroindirubin | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 7-bromo-N-methylindirubin | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 7-bromo-N-methylindirubin-3'-acetoxime | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 7-bromo-N-methylindirubin-3'-methoxime | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 7-bromo-N-methylindirubin-3'-oxime | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 7-bromoindirubin | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 7-bromoindirubin-3'-methoxime | |
0.05 | - |
pH not specified in the publication, 30°C | Oryctolagus cuniculus | 7-carboxylindirubin | |
0.05 | - |
pH not spefified in the publication, 30°C | Oryctolagus cuniculus | indirubin |