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Literature summary for 2.7.11.19 extracted from

  • Boulatnikov, I.G.; Nadeau, O.W.; Daniels, P.J.; Sage, J.M.; Jeyasingham, M.D.; Villar, M.T.; Artigues, A.; Carlson, G.M.
    The regulatory beta subunit of phosphorylase kinase interacts with glyceraldehyde-3-phosphate dehydrogenase (2008), Biochemistry, 47, 7228-7236.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.19

Cloned(Commentary)

Cloned (Comment) Organism
alpha, gamma, delta-trimer, complex is shown to be unable to phosphorylate glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
glyceraldehyde-3-phosphate dehydrogenase
-
 Mus musculus
glyceraldehyde-3-phosphate dehydrogenase
-
 Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+-dependent reaction Mus musculus
Ca2+ Ca2+-dependent reaction Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
16700
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Mus musculus
16700
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Oryctolagus cuniculus
44700
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Mus musculus
44700
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Oryctolagus cuniculus
125200
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Mus musculus
125200
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Oryctolagus cuniculus
138400
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Mus musculus
138400
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycogen phosphorylase b + ATP Mus musculus phosphorylates and activates glycogen phosphorylase b, couples muscle contraction with glycogen breakdown glycogen phosphorylase a + ADP
-
 ?
glycogen phosphorylase b + ATP Oryctolagus cuniculus phosphorylates and activates glycogen phosphorylase b, couples muscle contraction with glycogen breakdown glycogen phosphorylase a + ADP
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Oryctolagus cuniculus
-
 New Zealand white rabbit
-

Purification (Commentary)

Purification (Comment) Organism
-
 Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
muscle psoas muscle Oryctolagus cuniculus
-
skeletal muscle from back and leg Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glyceraldehyde-3-phosphate dehydrogenase + ATP phosphorylation is very slow, binds tightly to enzyme and acts as inhibitor for the phosphorylation of glycogen phosphorylase b Mus musculus ?
-
 ?
glyceraldehyde-3-phosphate dehydrogenase + ATP phosphorylation is very slow, binds tightly to enzyme and acts as inhibitor for the phosphorylation of glycogen phosphorylase b Oryctolagus cuniculus ?
-
 ?
glycogen phosphorylase b + ATP
-
 Mus musculus glycogen phosphorylase a + ADP
-
 ?
glycogen phosphorylase b + ATP
-
 Oryctolagus cuniculus glycogen phosphorylase a + ADP
-
 ?
glycogen phosphorylase b + ATP phosphorylates and activates glycogen phosphorylase b, couples muscle contraction with glycogen breakdown Mus musculus glycogen phosphorylase a + ADP
-
 ?
glycogen phosphorylase b + ATP phosphorylates and activates glycogen phosphorylase b, couples muscle contraction with glycogen breakdown Oryctolagus cuniculus glycogen phosphorylase a + ADP
-
 ?
SDQEKRKQISVRGL + ATP artificial substrate Oryctolagus cuniculus ?
-
 ?

Subunits

Subunits Comment Organism
hexadecamer alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Mus musculus
hexadecamer alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Oryctolagus cuniculus

Synonyms

Synonyms Comment Organism
EC 2.7.1.38 formerly, transferred to EC 2.7.11.19 Mus musculus
EC 2.7.1.38 formerly, transferred to EC 2.7.11.19 Oryctolagus cuniculus
PhK
-
 Mus musculus
PhK
-
 Oryctolagus cuniculus
Phosphorylase b kinase
-
 Mus musculus
Phosphorylase b kinase
-
 Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00045
-
-
 Oryctolagus cuniculus glyceraldehyde-3-phosphate dehydrogenase