Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Catalytic subunit of cAMP-dependent protein kinase | activation of nonactivated enzyme | Oryctolagus cuniculus | |
additional information | autophosphorylation | Oryctolagus cuniculus | |
additional information | the nonactivated enzyme is activated either by limited proteolysis | Oryctolagus cuniculus | |
additional information | three separate activities can be characterized by their response to Ca2+, Mg2+, NH4Cl and pH: A0, A1 and A2 | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NH4Cl | - |
Oryctolagus cuniculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+-independent activity: A0 | Oryctolagus cuniculus | |
Ca2+ | stimulates autophosphorylation in micromolar range at pH 6.8, inhibits at millimolar range | Oryctolagus cuniculus | |
Ca2+ | required for activity and activation | Oryctolagus cuniculus | |
Mg2+ | requirement | Oryctolagus cuniculus | |
Mg2+ | major role of Mg2+: cosubstrate in Mg2+-ATP complex | Oryctolagus cuniculus | |
additional information | three separate activities can be characterized by their response to Ca2+, Mg2+, NH4Cl and pH: A0, A1 and A2 | Oryctolagus cuniculus | |
phosphate | requirement, phosphate containing enzyme | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + nonactivated phosphorylase kinase | i.e. autophosphorylation and autoactivation | Oryctolagus cuniculus | ADP + activated phosphorylase kinase | - |
? | |
ATP + phosphorylase b | cosubstrate: Mg-ATP complex | Oryctolagus cuniculus | ADP + phosphorylase a | - |
? | |
ATP + troponin I | - |
Oryctolagus cuniculus | ADP + phosphotroponin I | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Oryctolagus cuniculus |