Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | dependent on | Mus musculus | |
Calmodulin | dependent on | Homo sapiens | |
Calmodulin | dependent on | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ML-7 | i.e. 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine | Homo sapiens | |
ML-7 | i.e. 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine | Mus musculus | |
ML-7 | i.e. 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine | Rattus norvegicus | |
ML-9 | i.e. 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine, inhibits MLCK and paracellular permeability increases in several intestinal epithelial models | Homo sapiens | |
ML-9 | i.e. 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine, inhibits MLCK and paracellular permeability increases in several intestinal epithelial models | Mus musculus | |
ML-9 | i.e. 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine, inhibits MLCK and paracellular permeability increases in several intestinal epithelial models | Rattus norvegicus | |
additional information | inhibitor effects on enzyme activity in intestinal tissues, overview | Homo sapiens | |
additional information | inhibitor effects on enzyme activity in intestinal tissues, overview | Mus musculus | |
additional information | inhibitor effects on enzyme activity in intestinal tissues, overview | Rattus norvegicus | |
RKKYKYRRK-NH2 | i.e. D PIK | Homo sapiens | |
RKKYKYRRK-NH2 | i.e. D PIK | Mus musculus | |
RKKYKYRRK-NH2 | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Mus musculus | |
Ca2+ | dependent on | Homo sapiens | |
Ca2+ | dependent on | Rattus norvegicus | |
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myosin light chain | Mus musculus | - |
ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | Homo sapiens | - |
ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | Rattus norvegicus | - |
ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | Mus musculus C57BL/6 | - |
ADP + myosin light chain phosphate | - |
? | |
additional information | Homo sapiens | cytochalasin-induced increases in paracellular permeability are also mediated by MLC in Caco-2 monolayers | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Rattus norvegicus | - |
adult male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |
colon | - |
Mus musculus | - |
colon | - |
Rattus norvegicus | - |
colon | from patients who had not been treated with chemotherapy or radiotherapy, freshlys collected at the time of surgical resection for malignant or non-inflammatory disease | Homo sapiens | - |
epithelium | - |
Mus musculus | - |
epithelium | - |
Homo sapiens | - |
epithelium | - |
Rattus norvegicus | - |
intestine | mucosa | Mus musculus | - |
intestine | mucosa | Homo sapiens | - |
intestine | mucosa | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myosin light chain | - |
Mus musculus | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | - |
Homo sapiens | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | - |
Rattus norvegicus | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | - |
Mus musculus C57BL/6 | ADP + myosin light chain phosphate | - |
? | |
additional information | cytochalasin-induced increases in paracellular permeability are also mediated by MLC in Caco-2 monolayers | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MLC kinase | - |
Mus musculus |
MLC kinase | - |
Homo sapiens |
MLC kinase | - |
Rattus norvegicus |
MLCK | - |
Mus musculus |
MLCK | - |
Homo sapiens |
MLCK | - |
Rattus norvegicus |
myosin light chain kinase | - |
Mus musculus |
myosin light chain kinase | - |
Homo sapiens |
myosin light chain kinase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.029 | - |
- |
Homo sapiens | RKKYKYRRK-NH2 |