Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KKRAARATS-NH2 | i.e. KKRAARATS amide | Homo sapiens | |
ML-7 | a specific MLCK inhibitor | Homo sapiens | |
additional information | protein kinase A inhibits MLCK and myosin loght chain dephosphorylation, the latter via effects on the Rho kinase/MLC phosphatase pathway, reversible by KT5720, an inhibitor of PKA. Inhibition of MLC phosphorylation leads to beta2-integrin activation and adhesion, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myosin light chain | Homo sapiens | - |
ADP + myosin light chain phosphate | - |
? | |
additional information | Homo sapiens | PKA regulates beta2-integrin avidity activation via a MLCK-dependent pathway, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myosin light chain | - |
Homo sapiens | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | phosphorylation at Ser19 | Homo sapiens | ADP + myosin light chain phosphate | - |
? | |
additional information | PKA regulates beta2-integrin avidity activation via a MLCK-dependent pathway, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MLC kinase | - |
Homo sapiens |
MLCK | - |
Homo sapiens |
myosin light-chain kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |