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Literature summary for 2.7.11.18 extracted from

  • Chilcoat, C.D.; Sharief, Y.; Jones, S.L.
    Tonic protein kinase A activity maintains inactive beta2 integrins in unstimulated neutrophils by reducing myosin light-chain phosphorylation: role of myosin light-chain kinase and Rho kinase (2008), J. Leukoc. Biol., 83, 964-971.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
KKRAARATS-NH2 i.e. KKRAARATS amide Homo sapiens
ML-7 a specific MLCK inhibitor Homo sapiens
additional information protein kinase A inhibits MLCK and myosin loght chain dephosphorylation, the latter via effects on the Rho kinase/MLC phosphatase pathway, reversible by KT5720, an inhibitor of PKA. Inhibition of MLC phosphorylation leads to beta2-integrin activation and adhesion, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + myosin light chain Homo sapiens
-
ADP + myosin light chain phosphate
-
?
additional information Homo sapiens PKA regulates beta2-integrin avidity activation via a MLCK-dependent pathway, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myosin light chain
-
Homo sapiens ADP + myosin light chain phosphate
-
?
ATP + myosin light chain phosphorylation at Ser19 Homo sapiens ADP + myosin light chain phosphate
-
?
additional information PKA regulates beta2-integrin avidity activation via a MLCK-dependent pathway, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
MLC kinase
-
Homo sapiens
MLCK
-
Homo sapiens
myosin light-chain kinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens