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Literature summary for 2.7.11.18 extracted from
- Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo (2008), Am. J. Physiol. Cell Physiol., 295, C358-C364.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | the enzyme is dependent on Ca2+ and calmodulin | Mus musculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Carbachol | increases Ca2+ concentration, MLCK activation and regulatory light chain phosphorylation | Mus musculus | |
| KCl | increases Ca2+ concentration, MLCK activation and regulatory light chain phosphorylation | Mus musculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | the enzyme is dependent on Ca2+ and calmodulin, the intracellular Ca2+ concentration has regulatory effect, overview | Mus musculus | |
| Mg2+ | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myosin regulatory light chain | Mus musculus | - |
ADP + phosphorylated myosin regulatory light chain | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bladder | - |
Mus musculus | - |
| smooth muscle | from bladder | Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myosin regulatory light chain | - |
Mus musculus | ADP + phosphorylated myosin regulatory light chain | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MLCK | - |
Mus musculus |
| myosin light chain kinase | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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