Cloned (Comment) | Organism |
---|---|
genes MYLK2 and MYLK3, DNA and amino acid sequence determination and analysis, expression analysis in heart | Danio rerio |
genes MYLK2 and MYLK3, DNA and amino acid sequence determination and analysis, expression analysis in heart, sequence comparisons | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of cardiac-MLCK by specific siRNAs decreases cardiac-MLCK phosphorylation and impairs epinephrine-induced activation of sarcomere reassembly, knockdown of zcardiac-MLCK expression using morpholino antisense oligonucleotides results in dilated cardiac ventricles and immature sarcomere structures | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Danio rerio |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + light chain myosin II | Homo sapiens | - |
ADP + phosphorylated light chain myosin II | - |
? | |
ATP + light chain myosin II | Danio rerio | cardiac-MLCK is essential for normal cardiac development and function in zebrafish embryos, deletion of the gene encoding cardiac-MLCK is lethal for embryos | ADP + phosphorylated light chain myosin II | - |
? | |
additional information | Homo sapiens | ventricular/cardiac muscle isozyme cardiac-MLCK, which is involved in the development of human cardiomyopathy, is an important structural protein that affects physiologic cardiac sarcomere formation and heart development, the cardiac MLCK regulates sarcomere assembly in the vertebrate heart, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | - |
cardiac/ventricular isozyme cardiac-MLCK encoded by gene MLCK3, and smooth muscle isozyme encoded by gene MLCK2 | - |
Homo sapiens | - |
cardiac/ventricular isozyme cardiac-MLCK encoded by gene MLCK3, and smooth muscle isozyme encoded by gene MLCK2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Danio rerio | - |
heart | specific cardiac/ventricular isozyme cardiac-MLCK | Danio rerio | - |
heart | specific cardiac/ventricular isozyme cardiac-MLCK encoded by gene MLCK3, expression analysis in healthy hearts and hearts from patients with heart failure | Homo sapiens | - |
additional information | tissue distribution analysis, overview | Homo sapiens | - |
myocardium | - |
Homo sapiens | - |
smooth muscle | specific smooth muscle isozyme smMLCK encoded by gene MLCK2 | Homo sapiens | - |
smooth muscle | specific smooth muscle isozyme smMLCK encoded by gene MLCK2 | Danio rerio | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + light chain myosin II | - |
Homo sapiens | ADP + phosphorylated light chain myosin II | - |
? | |
ATP + light chain myosin II | cardiac-MLCK is essential for normal cardiac development and function in zebrafish embryos, deletion of the gene encoding cardiac-MLCK is lethal for embryos | Danio rerio | ADP + phosphorylated light chain myosin II | - |
? | |
ATP + light chain myosin II | the cardiac-specific substrate cardiac-MLCKis phosphorylated by the cardiac-specific isozyme MLC2v | Danio rerio | ADP + phosphorylated light chain myosin II | - |
? | |
ATP + light chain myosin II | the cardiac-specific substrate MLC2v is phosphorylated by the cardiac-specific isozyme cardiac-MLCK | Homo sapiens | ADP + phosphorylated light chain myosin II | - |
? | |
additional information | ventricular/cardiac muscle isozyme cardiac-MLCK, which is involved in the development of human cardiomyopathy, is an important structural protein that affects physiologic cardiac sarcomere formation and heart development, the cardiac MLCK regulates sarcomere assembly in the vertebrate heart, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cardiac-MLCK | - |
Homo sapiens |
cardiac-MLCK | - |
Danio rerio |
MLCK | - |
Homo sapiens |
MLCK | - |
Danio rerio |
myosin light chain kinase | - |
Homo sapiens |
myosin light chain kinase | - |
Danio rerio |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Danio rerio |