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Literature summary for 2.7.11.18 extracted from

  • Connell, L.E.; Helfman, D.M.
    Myosin light chain kinase plays a role in the regulation of epithelial cell survival (2006), J. Cell Sci., 119, 2269-2281.
    View publication on PubMed
Search for more literature for 2.7.11.18

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and dominant-negative MLCK in untransformed and Ras-transformed MCF-10A cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of a dominant-negative MLCK mutant Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
ML-7 inhibition of MLCK induces apoptosis in adherent cells and disrupts cell-cell adhesion Mus musculus
ML-9 inhibition of MLCK induces apoptosis in adherent cells and disrupts cell-cell adhesion Mus musculus
additional information no inhibition in vivo by Y-27632 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + light chain myosin II Mus musculus myosin II activation is essential for stress fiber and focal adhesion formation, and is implicated in integrin-mediated signaling events ADP + phosphorylated light chain myosin II
-
 ?
additional information Mus musculus the myosin light chain kinase plays a role in the regulation of epithelial cell survival, and in the generation of pro-survival signals in both untransformed and transformed epithelial cells, apoptosis following inhibition of myosin II activation by MLCK is probably meditated through the death receptor pathway, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + light chain myosin II
-
 Mus musculus ADP + phosphorylated light chain myosin II
-
 ?
ATP + light chain myosin II myosin II activation is essential for stress fiber and focal adhesion formation, and is implicated in integrin-mediated signaling events Mus musculus ADP + phosphorylated light chain myosin II
-
 ?
additional information the myosin light chain kinase plays a role in the regulation of epithelial cell survival, and in the generation of pro-survival signals in both untransformed and transformed epithelial cells, apoptosis following inhibition of myosin II activation by MLCK is probably meditated through the death receptor pathway, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
MLCK
-
 Mus musculus
myosin light chain kinase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus