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Literature summary for 2.7.11.18 extracted from
- The long myosin light chain kinase is differentially phosphorylated during interphase and mitosis (2004), Exp. Cell Res., 299, 303-314.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of GFP-tagged enzyme in HeLa cells | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on | Homo sapiens |  |
| Ca2+ | dependent on | Oryctolagus cuniculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 108000 | 125000 | short myosin light chain kinase | Oryctolagus cuniculus |
| 210000 | - |
long myosin light chain kinase | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [myosin light chain] | Homo sapiens | - |
ADP + [myosin light chain] phosphate | - |
? | |
| ATP + [myosin light chain] | Oryctolagus cuniculus | - |
ADP + [myosin light chain] phosphate | - |
? | |
| additional information | Homo sapiens | the enzyme activity is cell cycle regulated with a decrease in activity during mitosis due to phosphorylation, inhibition of enzyme phosphorylation during mitosis leads to microtubule defects, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
short enzyme form | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | diffential phosphorylation by Aurora B on serine residues during interphase and mitosis has regulatory function, phosphorylation sites for Aurora B on the enzyme, overview | Oryctolagus cuniculus |
| phosphoprotein | diffential phosphorylation by Aurora B on serine residues, e.g. in the enzyme's IgG domain, during interphase and mitosis has regulatory function, phosphorylation sites for Aurora B on the enzyme, overview | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant GFP-fusion enzyme from HeLa cells | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [myosin light chain] | - |
Homo sapiens | ADP + [myosin light chain] phosphate | - |
? | |
| ATP + [myosin light chain] | - |
Oryctolagus cuniculus | ADP + [myosin light chain] phosphate | - |
? | |
| additional information | the enzyme activity is cell cycle regulated with a decrease in activity during mitosis due to phosphorylation, inhibition of enzyme phosphorylation during mitosis leads to microtubule defects, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| long myosin light chain kinase | - |
Homo sapiens |
| short myosin light chain kinase | - |
Oryctolagus cuniculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| ATP | - |
Oryctolagus cuniculus | |
| Calmodulin | dependent on | Homo sapiens | |
| Calmodulin | dependent on | Oryctolagus cuniculus | |
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Release 2023.1 (January 2023)
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