Literature summary for 2.7.11.18 extracted from

Rogers, J.C.; Williams, D.L.
Kaempferol inhibits myosin light chain kinase (1989), Biochem. Biophys. Res. Commun., 164, 419-425.

Search for more literature for 2.7.11.18

Inhibitors

Inhibitors	Comment	Organism	Structure
kaempferol	i.e. 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-1-benzopyran-4-one, IC50: 0.00045 mM	Bos taurus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.005	0.0095	myosin light chain	30°C, pH 7.2	Bos taurus
0.075	-	ATP	-	Bos taurus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	-	Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + myosin light chain	Bos taurus	obligatory step in development of active tension in smooth muscle	ADP + myosin light chain phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aorta	thoracic	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + myosin light chain	-	Bos taurus	ADP + myosin light chain phosphate	-	?
ATP + myosin light chain	obligatory step in development of active tension in smooth muscle	Bos taurus	ADP + myosin light chain phosphate	-	?

Cofactor

Cofactor	Comment	Organism	Structure
Calmodulin	requirement	Bos taurus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00045	-	i.e. 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-1-benzopyran-4-one, IC50: 0.00045 mM	Bos taurus	kaempferol

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Release 2023.1 (January 2023)