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Literature summary for 2.7.11.17 extracted from
- Activated Ca2+/calmodulin-dependent protein kinase IIgamma is a critical regulator of myeloid leukemia cell proliferation (2008), Cancer Res., 68, 3733-3742.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in the LXSN retroviral expression vector M28248 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| imatinib | downregulates CaMKIIgamma autophosphorylation/activation | Homo sapiens |  |
| KN-62 | - |
Homo sapiens | |
| KN-93 | inhibits CaMKII activity by blocking its interaction with the Ca2+/calmodulin complex | Homo sapiens | |
| additional information | not inhibited by AG490, JAK3 inhibitor, PP1, PD98059, U0126, SB203580, wortmannin, LY294002, c-Jun NH2-terminal kinase inhibitor II, Raf 1 inhibitor, pho kinase inhibitor, RO-31-8220, Go6983, cucurbitacin I, Gleevec, and AMPK inhibitor | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q13555 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| acute myeloid leukemia cell | - |
Homo sapiens | - |
| chronic myeloid leukemia cell | - |
Homo sapiens | - |
| DAUDI cell | - |
Homo sapiens | - |
| DHL-4 cell | - |
Homo sapiens | - |
| HL-60 cell | - |
Homo sapiens | - |
| JURKAT cell | - |
Homo sapiens | - |
| K-562 cell | - |
Homo sapiens | - |
| Kasumi-1 cell | - |
Homo sapiens | - |
| KCL-22 cell | - |
Homo sapiens | - |
| KG-1 cell | - |
Homo sapiens | - |
| myeloid leukemia cell | - |
Homo sapiens | - |
| NB-4 cell | - |
Homo sapiens | - |
| RAJI cell | - |
Homo sapiens | - |
| Ramos cell | - |
Homo sapiens | - |
| THP-1 cell | - |
Homo sapiens | - |
| U-937 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + STAT3 | - |
Homo sapiens | ADP + phosphorylated STAT3 | - |
? | |
| additional information | CaMKIIgamma is activated by autophosphorylation | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ca2+/calmodulin-dependent protein kinase IIgamma | - |
Homo sapiens |
| CaMKIIgamma | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| Calmodulin | dependent on | Homo sapiens | |
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Release 2023.1 (January 2023)
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