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Literature summary for 2.7.11.17 extracted from

  • Tsui, J.; Malenka, R.C.
    Substrate localization creates specificity in calcium/calmodulin-dependent protein kinase II signaling at synapses (2006), J. Biol. Chem., 281, 13794-13804.
    View publication on PubMed
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of CaMKII in HEK-293 cells, and expression of CaMKII in cultured neurons using lentiviral transfection, co-expression of protein substrates Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
KN-93
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Homo sapiens
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + glutamate receptor subunit GluR1 Homo sapiens low activity, CaMKII, membrane localization of GluR1 restricts its phosphorylation ADP + phosphorylated glutamate receptor subunit GluR1
-
 ?
ATP + glutamate receptor subunit NR2B Homo sapiens low activity, CaMKII ADP + phosphorylated glutamate receptor subunit NR2B
-
 ?
ATP + PSD-95 Homo sapiens high activity, CaMKII, smaller synapses show greater variability in PSD-95 phosphorylation ADP + phosphorylated PSD-95
-
 ?
ATP + Stargazin Homo sapiens high activity, CaMKII, phosphatases limit phosphorylation of stargazin ADP + phosphorylated Stargazin
-
 ?
additional information Homo sapiens CaMKII is a major component of the postsynaptic density of excitatory synapses, and plays a key role in the regulation of synaptic function in the mammalian brain, the unique molecular architecture of the postsynaptic density results in highly selective substrate discrimination by CaMKII, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + glutamate receptor subunit GluR1 low activity, CaMKII, membrane localization of GluR1 restricts its phosphorylation Homo sapiens ADP + phosphorylated glutamate receptor subunit GluR1
-
 ?
ATP + glutamate receptor subunit GluR1 phosphorylation at Ser831 Homo sapiens ADP + phosphorylated glutamate receptor subunit GluR1
-
 ?
ATP + glutamate receptor subunit NR2B
-
 Homo sapiens ADP + phosphorylated glutamate receptor subunit NR2B
-
 ?
ATP + glutamate receptor subunit NR2B low activity, CaMKII Homo sapiens ADP + phosphorylated glutamate receptor subunit NR2B
-
 ?
ATP + PSD-95 high activity, CaMKII, smaller synapses show greater variability in PSD-95 phosphorylation Homo sapiens ADP + phosphorylated PSD-95
-
 ?
ATP + PSD-95 a protein implicated in the scaffolding and trafficking of AMPA receptors Homo sapiens ADP + phosphorylated PSD-95
-
 ?
ATP + Stargazin high activity, CaMKII, phosphatases limit phosphorylation of stargazin Homo sapiens ADP + phosphorylated Stargazin
-
 ?
ATP + Stargazin a protein implicated in the scaffolding and trafficking of AMPA receptors Homo sapiens ADP + phosphorylated Stargazin
-
 ?
additional information CaMKII is a major component of the postsynaptic density of excitatory synapses, and plays a key role in the regulation of synaptic function in the mammalian brain, the unique molecular architecture of the postsynaptic density results in highly selective substrate discrimination by CaMKII, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
calcium/calmodulin-dependent protein kinase II
-
 Homo sapiens
CaMKII
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens