Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | - |
Homo sapiens | |
ionomycin | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
transient co-expression of CaMKIV, MEF-2, and Cabin1 in murine T-cell hybridoma DO11.10, MEF-2 activation of gene transcription is inhibited by Cabin1, the inhibition is reversed by CaMKIV | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K75E | site-directed mutagenesis, catalytically inactive CaMKIV mutant | Homo sapiens |
additional information | introduction of lentivirus shRNA specific for human CaMKIV into human T-cells and Jurkat cells leads to knockdown of CaMKIV expression | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KN-62 | - |
Homo sapiens | |
W-7 | no inhibition by calcineurin inhibitor FK506 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens | |
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Cabin1 | Homo sapiens | a transcriptional corepressor of myocyte enhancer factor 2, phosphorylation by CaMKIV creates a docking site for protein 14-3-3, which causes nuclear export, CaMKIV regulates nuclear export of Cabin1 during Ca2+-dependent T-cell activation, regulation overview | ADP + phosphorylated Cabin1 | - |
? | |
additional information | Homo sapiens | Ca2+ signaling in T-cell activation involves transcriptional activity of MEF-2 and NFAT, which is repressed by Cabin1, activated CaMKIV can overcome the repression by Cabin1, crosstalk between Cabin1 and CaMKIV, dissociation of Cabin1 from MEF-2 by the enzyme requires calmodulin, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-lymphocyte | primary | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Cabin1 | a transcriptional corepressor of myocyte enhancer factor 2, phosphorylation by CaMKIV creates a docking site for protein 14-3-3, which causes nuclear export, CaMKIV regulates nuclear export of Cabin1 during Ca2+-dependent T-cell activation, regulation overview | Homo sapiens | ADP + phosphorylated Cabin1 | - |
? | |
ATP + Cabin1 | a transcriptional corepressor of myocyte enhancer factor 2, phosphorylation at Ser2126 by CaMKIV creates a docking site for protein 14-3-3, which causes nuclear export, no activity with Cabin1 mutant S2126A | Homo sapiens | ADP + phosphorylated Cabin1 | - |
? | |
additional information | Ca2+ signaling in T-cell activation involves transcriptional activity of MEF-2 and NFAT, which is repressed by Cabin1, activated CaMKIV can overcome the repression by Cabin1, crosstalk between Cabin1 and CaMKIV, dissociation of Cabin1 from MEF-2 by the enzyme requires calmodulin, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calmodulin-dependent protein kinase IV | - |
Homo sapiens |
CaMKIV | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |