Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin | Mus musculus | |
Calmodulin | dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin | Homo sapiens | |
Calmodulin | dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin | Rattus norvegicus | |
Calmodulin | dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin | Sus scrofa | |
Calmodulin | dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin | Oryctolagus cuniculus | |
additional information | the enzyme is regulated by de-/phosphorylation | Mus musculus | |
additional information | the enzyme is regulated by de-/phosphorylation | Homo sapiens | |
additional information | the enzyme is regulated by de-/phosphorylation | Rattus norvegicus | |
additional information | the enzyme is regulated by de-/phosphorylation | Sus scrofa | |
additional information | the enzyme is regulated by de-/phosphorylation | Oryctolagus cuniculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of transgenic mice overexpressing calmodulin, the mutant mice develop severe cardiac hypertrophy and show increased Ca2+/calmodulin-independent CaMKII activity, overexpression of CaMKIV and CaMKIV knockout also lead to development of cardiac hypertrophy, CaMKIIdeltaB overexpressing transgenic mice do not phosphorylate CREB | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KN-93 | - |
Homo sapiens | |
KN-93 | - |
Mus musculus | |
KN-93 | - |
Oryctolagus cuniculus | |
KN-93 | - |
Rattus norvegicus | |
KN-93 | - |
Sus scrofa | |
additional information | CaMKII possesses an autoinhibitory domain, the enzyme is regulated by de-/phosphorylation | Homo sapiens | |
additional information | CaMKII possesses an autinhibitory domain, the enzyme is regulated by de-/phosphorylation | Mus musculus | |
additional information | CaMKII possesses an autoinhibitory domain, the enzyme is regulated by de-/phosphorylation | Oryctolagus cuniculus | |
additional information | CaMKII possesses an autoinhibitory domain, the enzyme is regulated by de-/phosphorylation | Rattus norvegicus | |
additional information | CaMKII possesses an autoinhibitory domain, the enzyme is regulated by de-/phosphorylation | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | isozyme CaMKIIdelta splicing variant deltaC, CaMKIV | Mus musculus | 5737 | - |
cytoplasm | isozyme CaMKIIdelta splicing variant deltaC, CaMKIV | Homo sapiens | 5737 | - |
cytoplasm | isozyme CaMKIIdelta splicing variant deltaC, CaMKIV | Rattus norvegicus | 5737 | - |
cytoplasm | isozyme CaMKIIdelta splicing variant deltaC, CaMKIV | Sus scrofa | 5737 | - |
cytoplasm | isozyme CaMKIIdelta splicing variant deltaC, CaMKIV | Oryctolagus cuniculus | 5737 | - |
nucleus | isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly | Mus musculus | 5634 | - |
nucleus | isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly | Homo sapiens | 5634 | - |
nucleus | isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly | Rattus norvegicus | 5634 | - |
nucleus | isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly | Sus scrofa | 5634 | - |
nucleus | isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly | Oryctolagus cuniculus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin | Mus musculus | |
Ca2+ | dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin | Homo sapiens | |
Ca2+ | dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin | Rattus norvegicus | |
Ca2+ | dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin | Sus scrofa | |
Ca2+ | dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + cAMP-response element binding protein | Rattus norvegicus | i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133 | ADP + phosphorylated cAMP-response element binding protein | - |
? | |
ATP + cAMP-response element binding protein | Mus musculus | i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 | ADP + phosphorylated cAMP-response element binding protein | - |
? | |
ATP + cAMP-response element binding protein | Homo sapiens | i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 | ADP + phosphorylated cAMP-response element binding protein | - |
? | |
ATP + cAMP-response element binding protein | Sus scrofa | i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 | ADP + phosphorylated cAMP-response element binding protein | - |
? | |
ATP + cAMP-response element binding protein | Oryctolagus cuniculus | i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 | ADP + phosphorylated cAMP-response element binding protein | - |
? | |
ATP + MEF-2A | Mus musculus | phosphorylation by CaMKIV | ADP + phosphorylated MEF-2A | - |
? | |
ATP + MEF-2C | Mus musculus | phosphorylation by CaMKIV | ADP + phosphorylated MEF-2C | - |
? | |
ATP + MEF-2D | Mus musculus | phosphorylation by CaMKIV | ADP + phosphorylated MEF-2D | - |
? | |
additional information | Mus musculus | CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview | ? | - |
? | |
additional information | Rattus norvegicus | CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview | ? | - |
? | |
additional information | Sus scrofa | CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview | ? | - |
? | |
additional information | Oryctolagus cuniculus | CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview | ? | - |
? | |
additional information | Homo sapiens | CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy, CaMKIIdeltaB expression is increased in heart failure, about 2fold in failing cardiomyopathy, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart | - |
Mus musculus | - |
isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart | - |
Oryctolagus cuniculus | - |
isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart | - |
Rattus norvegicus | - |
isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart | - |
Sus scrofa | - |
isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as well as at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin | Homo sapiens |
phosphoprotein | Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as well as at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin | Rattus norvegicus |
phosphoprotein | Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as well as at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin | Sus scrofa |
phosphoprotein | Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as well as at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin | Oryctolagus cuniculus |
phosphoprotein | Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as wellas at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiac muscle | - |
Mus musculus | - |
cardiac muscle | - |
Homo sapiens | - |
cardiac muscle | - |
Rattus norvegicus | - |
cardiac muscle | - |
Sus scrofa | - |
cardiac muscle | - |
Oryctolagus cuniculus | - |
heart | CaMKII, no expression of CaMKIV | Mus musculus | - |
heart | CaMKII, no expression of CaMKIV | Homo sapiens | - |
heart | CaMKII, no expression of CaMKIV | Rattus norvegicus | - |
heart | CaMKII, no expression of CaMKIV | Sus scrofa | - |
heart | CaMKII, no expression of CaMKIV | Oryctolagus cuniculus | - |
additional information | ubiquitous expression of CaMKII | Mus musculus | - |
additional information | ubiquitous expression of CaMKII | Homo sapiens | - |
additional information | ubiquitous expression of CaMKII | Rattus norvegicus | - |
additional information | ubiquitous expression of CaMKII | Sus scrofa | - |
additional information | ubiquitous expression of CaMKII | Oryctolagus cuniculus | - |
myocardium | isozyme CaMKIIdelta splicing variants deltaB and deltaC | Mus musculus | - |
myocardium | isozyme CaMKIIdelta splicing variants deltaB and deltaC | Homo sapiens | - |
myocardium | isozyme CaMKIIdelta splicing variants deltaB and deltaC | Rattus norvegicus | - |
myocardium | isozyme CaMKIIdelta splicing variants deltaB and deltaC | Sus scrofa | - |
myocardium | isozyme CaMKIIdelta splicing variants deltaB and deltaC | Oryctolagus cuniculus | - |
neuron | CaMKIV | Mus musculus | - |
neuron | CaMKIV | Homo sapiens | - |
neuron | CaMKIV | Rattus norvegicus | - |
neuron | CaMKIV | Sus scrofa | - |
neuron | CaMKIV | Oryctolagus cuniculus | - |
T-lymphocyte | CaMKIV | Mus musculus | - |
T-lymphocyte | CaMKIV | Homo sapiens | - |
T-lymphocyte | CaMKIV | Rattus norvegicus | - |
T-lymphocyte | CaMKIV | Sus scrofa | - |
T-lymphocyte | CaMKIV | Oryctolagus cuniculus | - |
testis | CaMKIV | Mus musculus | - |
testis | CaMKIV | Homo sapiens | - |
testis | CaMKIV | Rattus norvegicus | - |
testis | CaMKIV | Sus scrofa | - |
testis | CaMKIV | Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + cAMP-response element binding protein | i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133 | Rattus norvegicus | ADP + phosphorylated cAMP-response element binding protein | - |
? | |
ATP + cAMP-response element binding protein | i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 | Mus musculus | ADP + phosphorylated cAMP-response element binding protein | - |
? | |
ATP + cAMP-response element binding protein | i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 | Homo sapiens | ADP + phosphorylated cAMP-response element binding protein | - |
? | |
ATP + cAMP-response element binding protein | i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 | Rattus norvegicus | ADP + phosphorylated cAMP-response element binding protein | - |
? | |
ATP + cAMP-response element binding protein | i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 | Sus scrofa | ADP + phosphorylated cAMP-response element binding protein | - |
? | |
ATP + cAMP-response element binding protein | i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 | Oryctolagus cuniculus | ADP + phosphorylated cAMP-response element binding protein | - |
? | |
ATP + MEF-2A | phosphorylation by CaMKIV | Mus musculus | ADP + phosphorylated MEF-2A | - |
? | |
ATP + MEF-2C | phosphorylation by CaMKIV | Mus musculus | ADP + phosphorylated MEF-2C | - |
? | |
ATP + MEF-2D | phosphorylation by CaMKIV | Mus musculus | ADP + phosphorylated MEF-2D | - |
? | |
additional information | CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview | Mus musculus | ? | - |
? | |
additional information | CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview | Rattus norvegicus | ? | - |
? | |
additional information | CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview | Sus scrofa | ? | - |
? | |
additional information | CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview | Oryctolagus cuniculus | ? | - |
? | |
additional information | CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy, CaMKIIdeltaB expression is increased in heart failure, about 2fold in failing cardiomyopathy, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview | Homo sapiens | ? | - |
? | |
additional information | CaMKII is a multifunctional enzyme | Mus musculus | ? | - |
? | |
additional information | CaMKII is a multifunctional enzyme | Homo sapiens | ? | - |
? | |
additional information | CaMKII is a multifunctional enzyme | Rattus norvegicus | ? | - |
? | |
additional information | CaMKII is a multifunctional enzyme | Sus scrofa | ? | - |
? | |
additional information | CaMKII is a multifunctional enzyme | Oryctolagus cuniculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
multimer | CaMKII, hetero- or homomultimer | Homo sapiens |
multimer | CaMKII, hetero- or homomultimer | Rattus norvegicus |
multimer | CaMKII, hetero- or homomultimer | Sus scrofa |
multimer | CaMKII, hetero- or homomultimer | Oryctolagus cuniculus |
multimer | CaMKII, hetero-or homonultimer | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
Ca2+/calmodulin-dependent protein kinase II | - |
Mus musculus |
Ca2+/calmodulin-dependent protein kinase II | - |
Homo sapiens |
Ca2+/calmodulin-dependent protein kinase II | - |
Rattus norvegicus |
Ca2+/calmodulin-dependent protein kinase II | - |
Sus scrofa |
Ca2+/calmodulin-dependent protein kinase II | - |
Oryctolagus cuniculus |
CaMKII | - |
Mus musculus |
CaMKII | - |
Homo sapiens |
CaMKII | - |
Rattus norvegicus |
CaMKII | - |
Sus scrofa |
CaMKII | - |
Oryctolagus cuniculus |
CaMKIV | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus | |
ATP | - |
Sus scrofa | |
ATP | - |
Oryctolagus cuniculus |