Application | Comment | Organism |
---|---|---|
medicine | reducing enzyme protein expression in HeLa cells increases its sensitivity to paclitaxel and docetaxel and increases apoptosis in response to paclitaxel treatment | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [G-protein-coupled receptor] | Homo sapiens | - |
ADP + [G-protein-coupled receptor] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P34947 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
cervical carcinoma cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone deacetylase 6 | the enzyme phosphorylates histone deacetylase 6 at Ser21 to promote its deacetylase activity | Homo sapiens | ADP + phosphorylated histone deacetylase 6 | - |
? | |
ATP + [G-protein-coupled receptor] | - |
Homo sapiens | ADP + [G-protein-coupled receptor] phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 75000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
G protein-coupled receptor kinase 5 | - |
Homo sapiens |
GRK5 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme-histone deacetylase 6 interaction contributes to paclitaxel resistance in cancer cells | Homo sapiens |