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Literature summary for 2.7.11.16 extracted from

  • Michal, A.M.; So, C.H.; Beeharry, N.; Shankar, H.; Mashayekhi, R.; Yen, T.J.; Benovic, J.L.
    G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression (2012), J. Biol. Chem., 287, 6928-6940.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
K215R catalytically inactive mutant is not able to rescue the phenotype of HeLa GRK5 knockdown cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
centrosome GRK5 co-localizes with gamma-tubulin, centrin, and pericentrin in centrosomes. The centrosomal localization of GRK5 is observed predominantly at interphase and although its localization is not dependent on microtubules, it can mediate microtubule nucleation of centrosome Homo sapiens 5813
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
GRK5
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 Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown of GRK5 expression leads to G2/M arrest, characterized by a prolonged G2 phase, which can be rescued by expression of wild type but not catalytically inactive GRK5 Homo sapiens
physiological function GRK5 is localized in the centrosome and regulates microtubule nucleation and normal cell cycle progression Homo sapiens