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Literature summary for 2.7.11.16 extracted from

  • So, C.H.; Michal, A.M.; Mashayekhi, R.; Benovic, J.L.
    G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition (2012), J. Biol. Chem., 287, 17088-17099.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleophosmin 1 + ATP
-
 Homo sapiens phosphorylated nucleophosmin 1 + ADP
-
 ?

Synonyms

Synonyms Comment Organism
GRK5
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction GRK5-depleted cells are more sensitive to undergoing cell death from polo-like kinase 1 (PLK1) inhibition, and this increased susceptibility corresponds to decreased NPM1 phosphorylation. Conversely, cells with higher GRK5 levels exhibit reduced sensitivity to PLK1 inhibition Homo sapiens
physiological function GRK5 phosphorylates nucleophosmin and regulates the sensitivity of cells to PLK1 inhibition Homo sapiens