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Literature summary for 2.7.11.16 extracted from

  • Sorriento, D.; Ciccarelli, M.; Santulli, G.; Campanile, A.; Altobelli, G.G.; Cimini, V.; Galasso, G.; Astone, D.; Piscione, F.; Pastore, L.; Trimarco, B.; Iaccarino, G.
    The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha (2008), Proc. Natl. Acad. Sci. USA, 105, 17818-17823.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in BAEC cells and HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
K215R kinase-dead mutant of GRK5 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ATP + G protein-coupled receptor Homo sapiens
-
 ADP + phosphorylated G protein-coupled receptor
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ATP + G protein-coupled receptor
-
 Homo sapiens ADP + phosphorylated G protein-coupled receptor
-
 ?

Synonyms

Synonyms Comment Organism
G-protein-coupled receptor kinase 5
-
 Homo sapiens
GPCR kinase
-
 Homo sapiens
GRK5
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the RH domain of GRK5 interacts with IkappaBalpha and causes inhibition of NFkappaB activity, GRK5 overexpression causes nuclear accumulation of IkappaBalpha leading to the inhibition of NFkappaB transcriptional activity, the GRK5-RH domain inhibits TNFalpha transcription, inhibits endothelial cell migration, and vascular tube formation Homo sapiens