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Literature summary for 2.7.11.16 extracted from

  • Ribas, C.; Penela, P.; Murga, C.; Salcedo, A.; Garcia-Hoz, C.; Jurado-Pueyo, M.; Aymerich, I.; Mayor, F.
    The G protein-coupled receptor kinase (GRK) interactome: Role of GRKs in GPCR regulation and signaling (2007), Biochim. Biophys. Acta, 1768, 913-922.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information phosphorylation activates the enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
actin
-
Homo sapiens
alpha-actinin
-
Homo sapiens
Calmodulin
-
Homo sapiens
caveolin
-
Homo sapiens
RKIP
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mammalia 16020
-
nucleus GRK5 Mammalia 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
69000
-
x * 69000, GRK5, SDS-PAGE Homo sapiens
69000
-
x * 69000, about, GRK5 catalytic domain, domain structure, overview Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens GRK activity is regulated by phosphorylation through several kinases and by interactions with several cellular proteins, e.g. calmodulin, caveolin or RKIP, GRK also interacts with PI3K, Akt, GIT or MEK, the interactions occur at the RH and PH domains, overview, the GRK interactome: role of GRKs in GPCR regulation and signaling, detailed overview ?
-
?
additional information Mammalia G protein-coupled receptor kinases and arrestins are key participants in the canonical pathways leading to phosphorylation-dependent G protein-coupled receptor, GPCR, desensitization, endocytosis, intracellular trafficking and resensitization as well as in the modulation of important intracellular signaling cascades by GPCR, structure-function relationships, overview. GRK activity is tightly modulated by mechanisms including phosphorylation by different kinases and interaction with several cellular proteins such as calmodulin, caveolin or RKIP ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mammalia
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation, e.g. by PKA, PKC, ERK1/2 or c-SRC, activates the enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cerebellum GRK4 Mammalia
-
kidney GRK4 Mammalia
-
additional information GRK5 and GRK6 are ubiquitously expressed in mammalian tissues Mammalia
-
testis GRK4 Mammalia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GRK activity is regulated by phosphorylation through several kinases and by interactions with several cellular proteins, e.g. calmodulin, caveolin or RKIP, GRK also interacts with PI3K, Akt, GIT or MEK, the interactions occur at the RH and PH domains, overview, the GRK interactome: role of GRKs in GPCR regulation and signaling, detailed overview Homo sapiens ?
-
?
additional information G protein-coupled receptor kinases and arrestins are key participants in the canonical pathways leading to phosphorylation-dependent G protein-coupled receptor, GPCR, desensitization, endocytosis, intracellular trafficking and resensitization as well as in the modulation of important intracellular signaling cascades by GPCR, structure-function relationships, overview. GRK activity is tightly modulated by mechanisms including phosphorylation by different kinases and interaction with several cellular proteins such as calmodulin, caveolin or RKIP Mammalia ?
-
?
additional information no interaction of the RH domains of GRK5 and GRK6 with Galpha proteins. GRK5 contains a DNA-binding nuclear localization sequence that allows its binding to DNA and its localization in the nucleus upon GPCR activation, interaction with other oroteins, detailed overview Mammalia ?
-
?

Subunits

Subunits Comment Organism
? x * 69000, GRK5, SDS-PAGE Homo sapiens
? x * 69000, about, GRK5 catalytic domain, domain structure, overview Mammalia
More domain structure of GRK4-6, overview Homo sapiens

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase 5
-
Homo sapiens
GRK4
-
Mammalia
GRK4
-
Homo sapiens
GRK5
-
Mammalia
GRK5
-
Homo sapiens
GRK6
-
Mammalia
GRK6
-
Homo sapiens
More the enzyme belongs to the GRK4 subfamily Mammalia
More the enzyme belongs to the GRK4 subfamily Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens