Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [beta-adrenergic receptor] | Rattus norvegicus | - |
ADP + phospho-[beta-adrenergic receptor] | - |
? | |
additional information | Rattus norvegicus | RhoAGTP is a binding partner for enzyme GRK2 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
vascular smooth muscle cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [beta-adrenergic receptor] | - |
Rattus norvegicus | ADP + phospho-[beta-adrenergic receptor] | - |
? | |
additional information | RhoAGTP is a binding partner for enzyme GRK2 | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G protein-coupled receptor kinase 2 | - |
Rattus norvegicus |
GRK2 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
metabolism | G protein-coupled receptor kinase 2 is a RhoA effector that serves as a RhoA-activated scaffold protein for the ERK MAP kinase cascade | Rattus norvegicus |
physiological function | the enzyme is required for epidermal growth factor-induced, Rho- and ERK-dependent thymidine incorporation in vascular smooth muscle cells. Increased levels of GRK2 are associated with hypertension | Rattus norvegicus |