Cloned (Comment) | Organism |
---|---|
expressed in Sf9 clls using the baculovirus expression system | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
crystal structures of human GRK2 in complex with Gbetagamma in the presence and absence of the AGC (protein kinase A, kinase G, and kinase C subfamily) kinase inhibitor balanol is determined. Balanol stabilizes the kinase domain of GRK2 in a slightly more closed conformation distinct from that of the protein kinase A balanol complex | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
balanol | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P25098 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
tubulin + ATP | - |
Homo sapiens | phosphorylated-tubulin + ADP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GRK2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00005 | - |
pH 7.4, 20°C | Homo sapiens | balanol |