Literature summary for 2.7.11.15 extracted from

Lymperopoulos, A.; Rengo, G.; Zincarelli, C.; Soltys, S.; Koch, W.J.
Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity (2008), Mol. Ther., 16, 302-307.

Search for more literature for 2.7.11.15

Cloned(Commentary)

Cloned (Comment)	Organism
expression of GRK2 using an adenoviral expression system in suprerenal glands, the transgene-expression is restricted to the adrenal cortical region, overview	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
additional information	expression of GRK2 using an adenoviral expression system in suprerenal glands, the transgene-expression is restricted to the adrenal cortical region, overview, the method is not useful for effectively manipulating adrenal gland signalling, overview	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
betaARKct	a GRK2 inhibitor	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	GRK2 causes enhanced catecholamine secretion by desensitizing sympatho-inhibitory alpha2-adrenergic receptors of chromaffin cells and thereby aggravating heart failure	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P26819	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	GRK2 causes enhanced catecholamine secretion by desensitizing sympatho-inhibitory alpha2-adrenergic receptors of chromaffin cells and thereby aggravating heart failure	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
G protein-coupled receptor kinase-2	-	Rattus norvegicus
GRK2	-	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)