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Literature summary for 2.7.11.15 extracted from

  • Lorenz, S.; Frenzel, R.; Paschke, R.; Breitwieser, G.E.; Miedlich, S.U.
    Functional desensitization of the extracellular calcium-sensing receptor is regulated via distinct mechanisms: role of G protein-coupled receptor kinases, protein kinase C and beta-arrestins (2007), Endocrinology, 148, 2398-2404.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant GRK2 Homo sapiens

Protein Variants

Protein Variants Comment Organism
D110A the Galphaq binding site mutant of GRK 2 inhibits the inositol phosphate signal significantly less than wild-type GRK2, the mutant GRK 2 D110A still inhibitS inositol phosphate formation by 22.35 Homo sapiens
D110A/K220R the mutant inhibits the inositol phosphate signal significantly less than wild-type GRK2, but does not differ significantly from wild-type GRK2 in its ability to inhibit calcium-sensing receptor signaling Homo sapiens
K220R a catalytic site mutant of GRK2, the mutant does not differ significantly from wild-type GRK2 in its ability to inhibit calcium-sensing receptor signaling Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + calcium-sensing receptor Homo sapiens homologous desensitization of G protein-coupled receptors is generally mediated by GRKs through phosphorylation-dependent and independent mechanisms, GRK2 can phosphorylate calcium-sensing receptor and, along with beta-arrestins, can attenuate calcium-sensing receptor-mediated signaling, mechanism, overview ADP + calcium-sensing receptor phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P35626
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + calcium-sensing receptor GRK2 Homo sapiens ADP + calcium-sensing receptor phosphate
-
?
ATP + calcium-sensing receptor homologous desensitization of G protein-coupled receptors is generally mediated by GRKs through phosphorylation-dependent and independent mechanisms, GRK2 can phosphorylate calcium-sensing receptor and, along with beta-arrestins, can attenuate calcium-sensing receptor-mediated signaling, mechanism, overview Homo sapiens ADP + calcium-sensing receptor phosphate
-
?

Synonyms

Synonyms Comment Organism
GRK2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens