Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant GRK2 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D110A | the Galphaq binding site mutant of GRK 2 inhibits the inositol phosphate signal significantly less than wild-type GRK2, the mutant GRK 2 D110A still inhibitS inositol phosphate formation by 22.35 | Homo sapiens |
D110A/K220R | the mutant inhibits the inositol phosphate signal significantly less than wild-type GRK2, but does not differ significantly from wild-type GRK2 in its ability to inhibit calcium-sensing receptor signaling | Homo sapiens |
K220R | a catalytic site mutant of GRK2, the mutant does not differ significantly from wild-type GRK2 in its ability to inhibit calcium-sensing receptor signaling | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + calcium-sensing receptor | Homo sapiens | homologous desensitization of G protein-coupled receptors is generally mediated by GRKs through phosphorylation-dependent and independent mechanisms, GRK2 can phosphorylate calcium-sensing receptor and, along with beta-arrestins, can attenuate calcium-sensing receptor-mediated signaling, mechanism, overview | ADP + calcium-sensing receptor phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P35626 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + calcium-sensing receptor | GRK2 | Homo sapiens | ADP + calcium-sensing receptor phosphate | - |
? | |
ATP + calcium-sensing receptor | homologous desensitization of G protein-coupled receptors is generally mediated by GRKs through phosphorylation-dependent and independent mechanisms, GRK2 can phosphorylate calcium-sensing receptor and, along with beta-arrestins, can attenuate calcium-sensing receptor-mediated signaling, mechanism, overview | Homo sapiens | ADP + calcium-sensing receptor phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GRK2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |